| pubmed-article:7777500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7777500 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:7777500 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:7777500 | lifeskim:mentions | umls-concept:C1511625 | lld:lifeskim |
| pubmed-article:7777500 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:7777500 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:7777500 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:7777500 | pubmed:dateCreated | 1995-7-12 | lld:pubmed |
| pubmed-article:7777500 | pubmed:abstractText | c-Mpl, a member of the hematopoietic cytokine receptor family, is the receptor for thrombopoietin. To investigate signal transduction by c-Mpl, a chimeric receptor, composed of the extracellular domain of human growth hormone receptor and the intracellular domain of c-Mpl, was introduced into the interleukin 3-dependent cell line Ba/F3. In response to growth hormone, this chimeric receptor induced growth in the absence of interleukin 3. Deletion analysis of the 123-amino acid intracellular domain indicated that the elements responsible for this effect are present within the 63 amino acids proximal to the transmembrane domain. Mutation of the recently described box 1 motif abrogated the proliferative response. Tyrosine phosphorylation of the tyrosine kinase JAK-2 and activation of STAT proteins were dependent on box 1 and sequences within 63 amino acids of the plasma membrane. STAT proteins activated by thrombopoietin in a megakaryocytic cell line were purified and shown to be STAT1 and STAT3. A separate region located at the C terminus of the c-Mpl intracellular domain was found to be required for induction of Shc phosphorylation and c-fos mRNA accumulation, suggesting involvement of the Ras signal transduction pathway. Thus, at least two distinct regions are involved in signal transduction by the c-Mpl. | lld:pubmed |
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| pubmed-article:7777500 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7777500 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7777500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7777500 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7777500 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7777500 | pubmed:author | pubmed-author:WongS CSC | lld:pubmed |
| pubmed-article:7777500 | pubmed:author | pubmed-author:HenzelW JWJ | lld:pubmed |
| pubmed-article:7777500 | pubmed:author | pubmed-author:de SauvageF... | lld:pubmed |
| pubmed-article:7777500 | pubmed:author | pubmed-author:GurnerA CAC | lld:pubmed |
| pubmed-article:7777500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7777500 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:7777500 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7777500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7777500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7777500 | pubmed:pagination | 5292-6 | lld:pubmed |
| pubmed-article:7777500 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7777500 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7777500 | pubmed:articleTitle | Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. | lld:pubmed |
| pubmed-article:7777500 | pubmed:affiliation | Department of Molecular Biology, Genetech, Inc., South San Francisco, CA 94080, USA. | lld:pubmed |
| pubmed-article:7777500 | pubmed:publicationType | Journal Article | lld:pubmed |
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