| pubmed-article:7763438 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7763438 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7763438 | lifeskim:mentions | umls-concept:C0031001 | lld:lifeskim |
| pubmed-article:7763438 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:7763438 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:7763438 | lifeskim:mentions | umls-concept:C0549178 | lld:lifeskim |
| pubmed-article:7763438 | lifeskim:mentions | umls-concept:C0162339 | lld:lifeskim |
| pubmed-article:7763438 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7763438 | pubmed:dateCreated | 1993-4-6 | lld:pubmed |
| pubmed-article:7763438 | pubmed:abstractText | We describe here a continuous perfusion bioreactor system that enables a population of unselected human mononuclear bone marrow cells obtained from adult donors to expand up to 20 to 25-fold over a two-week period. Colony-forming units of granulocyte-macrophage (CFU-GM) progenitor cells expand 10 to 30-fold. These expansions depend on the gas phase oxygen concentration, the seeding density and time of cell harvest. Under operating conditions that allow for good cell proliferation, 3 to 4 million mononuclear cells can be obtained per square centimeter, with 0.5 to 0.8% being progenitor cells. Autologous human sera supported cell expansion as efficiently as animal sera. Increasing the size of the perfusion system to produce a clinically meaningful number of CFU-GMs could have important applications in bone marrow transplantation therapies. | lld:pubmed |
| pubmed-article:7763438 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7763438 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763438 | pubmed:citationSubset | B | lld:pubmed |
| pubmed-article:7763438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7763438 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7763438 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7763438 | pubmed:issn | 0733-222X | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:SilverSS | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:EmersonS GSG | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:FOXR ERE | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:SchwartzR MRM | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:NacuII | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:PalssonB OBO | lld:pubmed |
| pubmed-article:7763438 | pubmed:author | pubmed-author:PalssonMM | lld:pubmed |
| pubmed-article:7763438 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7763438 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:7763438 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7763438 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7763438 | pubmed:pagination | 368-72 | lld:pubmed |
| pubmed-article:7763438 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:meshHeading | pubmed-meshheading:7763438-... | lld:pubmed |
| pubmed-article:7763438 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7763438 | pubmed:articleTitle | Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system. | lld:pubmed |
| pubmed-article:7763438 | pubmed:affiliation | Department of Chemical Engineering, University of Michigan, Ann Arbor 48109. | lld:pubmed |
| pubmed-article:7763438 | pubmed:publicationType | Journal Article | lld:pubmed |
