| pubmed-article:7761445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7761445 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:7761445 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:7761445 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7761445 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7761445 | pubmed:abstractText | Like other cell-surface receptors with intrinsic or associated protein-tyrosine kinase activity, the T-cell receptor complex undergoes a number of modifications, including tyrosine phosphorylation steps, after ligand binding but before transmitting a signal. The requirement for these modifications introduces a temporal lag between ligand binding and receptor signaling. A model for the T-cell receptor is proposed in which this feature greatly enhances the receptor's ability to discriminate between a foreign antigen and self-antigens with only moderately lower affinity. The proposed scheme is a form of kinetic proofreading, known to be essential for the fidelity of protein and DNA synthesis. A variant of this scheme is also described in which a requirement for formation of large aggregates may lead to a further enhancement of the specificity of T-cell activation. Through these mechanisms, ligands of different affinity potentially may elicit qualitatively different signals. | lld:pubmed |
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| pubmed-article:7761445 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7761445 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7761445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7761445 | pubmed:month | May | lld:pubmed |
| pubmed-article:7761445 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7761445 | pubmed:author | pubmed-author:McKeithanT... | lld:pubmed |
| pubmed-article:7761445 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7761445 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:7761445 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7761445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7761445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7761445 | pubmed:pagination | 5042-6 | lld:pubmed |
| pubmed-article:7761445 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7761445 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7761445 | pubmed:articleTitle | Kinetic proofreading in T-cell receptor signal transduction. | lld:pubmed |
| pubmed-article:7761445 | pubmed:affiliation | Department of Pathology, University of Chicago, IL 60637, USA. | lld:pubmed |
| pubmed-article:7761445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7761445 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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