| pubmed-article:7759882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C0017296 | lld:lifeskim |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C0879338 | lld:lifeskim |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C0443211 | lld:lifeskim |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C1704419 | lld:lifeskim |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7759882 | lifeskim:mentions | umls-concept:C1514926 | lld:lifeskim |
| pubmed-article:7759882 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:7759882 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7759882 | pubmed:abstractText | Our recent studies using IL-12 protein or fibroblasts genetically engineered to secrete IL-12 have demonstrated profound antitumor effects of IL-12 in murine models. The antitumor effects of local, high level IL-12 expression were examined using a retroviral vector, which can express both IL-12 subunits (p35 and p40) and the neomycin phosphotransferase (Neo)-marker gene from a polycistronic message utilizing internal ribosome entry site sequences. All animals intradermally (i.d.) receiving MCA207 murine sarcoma cell line nontransfected or Neo-transfected had progressively growing tumor, whereas all animals injected with MCA207 transfected with IL-12 were tumor free and were subsequently determined to be immune to a rechallenge of nontransfected MCA207 i.d. Similar results were obtained in experiments using the poorly immunogenic MCA102 murine sarcoma cell line. The inoculation of live MCA207-IL-12 tumor cells also caused the regression of contralateral nontransfected MCA207 inoculated either at the same time (80% protection) or up to 3 days before (33% protection) to the therapeutic tumor inoculation. In vivo depletion studies suggest that NK cells and IFN-gamma play important roles in the development of the early phase of the antitumor response, but that T cells (both CD4+ and CD8+) play the major role in the subsequent events, leading to long-term immunity. The potent antitumor effects observed for paracrine gene-delivered administration of IL-12 have thus been confirmed for multiple tumor cell types and in multiple murine strains. We believe that these results support the feasibility of IL-12 gene therapy for the treatment of human cancer. | lld:pubmed |
| pubmed-article:7759882 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7759882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7759882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7759882 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7759882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7759882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7759882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7759882 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7759882 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:SchreiberR... | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:TaharaHH | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:GublerUU | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:LotzeM TMT | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:ZehH JHJ3rd | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:RobbinsP DPD | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:StorkusW JWJ | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:ZitvogelLL | lld:pubmed |
| pubmed-article:7759882 | pubmed:author | pubmed-author:McKinleyR CRC | lld:pubmed |
| pubmed-article:7759882 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7759882 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7759882 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:7759882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7759882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7759882 | pubmed:pagination | 6466-74 | lld:pubmed |
| pubmed-article:7759882 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:meshHeading | pubmed-meshheading:7759882-... | lld:pubmed |
| pubmed-article:7759882 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7759882 | pubmed:articleTitle | Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. | lld:pubmed |
| pubmed-article:7759882 | pubmed:affiliation | Department of Surgery, School of Medicine, Pittsburgh Cancer Institute, University of Pittsburgh, PA 15213, USA. | lld:pubmed |
| pubmed-article:7759882 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7759882 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7759882 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7759882 | lld:pubmed |
