| pubmed-article:7756488 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0001175 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0006837 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0226896 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0016277 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:7756488 | lifeskim:mentions | umls-concept:C0449435 | lld:lifeskim |
| pubmed-article:7756488 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7756488 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7756488 | pubmed:abstractText | Sixty-two Candida albicans isolates from the oral cavities of 28 patients with AIDS who were receiving fluconazole therapy were typed by restriction endonuclease analysis followed by pulsed-field gel electrophoresis; these isolates were then tested for fluconazole susceptibility by a standard broth dilution method. Sequential isolates (range, 2-4) were evaluated for 22 patients; only one isolate was evaluated for six patients. DNA subtyping revealed a total of 37 different DNA subtypes. Twelve (54.5%) of 22 patients with multiple episodes of oropharyngeal candidiasis were infected with a single DNA subtype throughout the observation period. Ten (45.5%) of 22 patients with multiple episodes of oropharyngeal candidiasis were infected with two or three DNA subtypes during the observation period. In vitro susceptibility tests revealed that MICs of fluconazole ranged from < or = 0.125 microgram/mL to 64 micrograms/mL, with an MIC50 of 0.5 microgram/mL and an MIC90 of 4 micrograms/mL. A significant increase in the MICs (fourfold or greater) of fluconazole for sequential C. albicans isolates was found for 66.6% of the patients infected with a single DNA subtype and for 50% of the patients infected with multiple DNA subtypes. Despite a limited number of patients and isolates, our data suggest that C. albicans isolates that are susceptible to fluconazole at MICs of > or = 8 micrograms/mL in vitro will be less susceptible in vivo to standard doses (100-200 mg/d) of this drug. | lld:pubmed |
| pubmed-article:7756488 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7756488 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7756488 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7756488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7756488 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7756488 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7756488 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7756488 | pubmed:issn | 1058-4838 | lld:pubmed |
| pubmed-article:7756488 | pubmed:author | pubmed-author:ScaliseGG | lld:pubmed |
| pubmed-article:7756488 | pubmed:author | pubmed-author:RinaldiM GMG | lld:pubmed |
| pubmed-article:7756488 | pubmed:author | pubmed-author:PfallerM AMA | lld:pubmed |
| pubmed-article:7756488 | pubmed:author | pubmed-author:BarchiesiFF | lld:pubmed |
| pubmed-article:7756488 | pubmed:author | pubmed-author:McGoughD ADA | lld:pubmed |
| pubmed-article:7756488 | pubmed:author | pubmed-author:HollisR JRJ | lld:pubmed |
| pubmed-article:7756488 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7756488 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:7756488 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7756488 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7756488 | pubmed:pagination | 634-40 | lld:pubmed |
| pubmed-article:7756488 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:meshHeading | pubmed-meshheading:7756488-... | lld:pubmed |
| pubmed-article:7756488 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7756488 | pubmed:articleTitle | DNA subtypes and fluconazole susceptibilities of Candida albicans isolates from the oral cavities of patients with AIDS. | lld:pubmed |
| pubmed-article:7756488 | pubmed:affiliation | Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750, USA. | lld:pubmed |
| pubmed-article:7756488 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7756488 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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