| pubmed-article:7747571 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0033209 | lld:lifeskim |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0005855 | lld:lifeskim |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0060520 | lld:lifeskim |
| pubmed-article:7747571 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:7747571 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7747571 | pubmed:dateCreated | 1995-6-12 | lld:pubmed |
| pubmed-article:7747571 | pubmed:abstractText | The effect of probenecid on the outward transport of fluorescein from vitreous to blood was studied in 13 insulin-dependent diabetic patients with background retinopathy in a randomised double-masked placebo controlled cross-over study. Fluorescein and fluorescein glucuronide was separated in the vitreous and in plasma by differential spectrofluorometry. The data for fluorescein were analysed using a simplified mathematical model of the eye. The inward permeability was estimated from data obtained 1 h after injection and the outward transport from data obtained 7 h after injection. During placebo treatment the mean inward permeability was 3.75 x 10(-7) cm/sec and the mean outward permeability was 2.25 x 10(-5) cm/sec. During probenecid treatment the mean inward permeability was 3.34 x 10(-7) cm/sec and the mean outward permeability was 1.44 x 10(-5) cm/sec. Thus, we found no significant change in inward permeability (p = 0.5879), whereas a significant decrease of 36% was found in the outward permeability of fluorescein (p = 0.0171). The demonstration that the outward permeability, which is more than 100-fold higher than the inward permeability in the healthy eye, is significantly decreased by probenecid, demonstrates that active transport is involved in movement of fluorescein across the blood-retina barrier from the vitreous to the plasma. | lld:pubmed |
| pubmed-article:7747571 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7747571 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7747571 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7747571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7747571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7747571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7747571 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7747571 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7747571 | pubmed:issn | 0001-639X | lld:pubmed |
| pubmed-article:7747571 | pubmed:author | pubmed-author:ParvingH HHH | lld:pubmed |
| pubmed-article:7747571 | pubmed:author | pubmed-author:LarsenMM | lld:pubmed |
| pubmed-article:7747571 | pubmed:author | pubmed-author:Lund-Andersen... | lld:pubmed |
| pubmed-article:7747571 | pubmed:author | pubmed-author:SanderBB | lld:pubmed |
| pubmed-article:7747571 | pubmed:author | pubmed-author:EnglerC BCB | lld:pubmed |
| pubmed-article:7747571 | pubmed:author | pubmed-author:KoefoedPP | lld:pubmed |
| pubmed-article:7747571 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7747571 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:7747571 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7747571 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7747571 | pubmed:pagination | 663-7 | lld:pubmed |
| pubmed-article:7747571 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
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| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:meshHeading | pubmed-meshheading:7747571-... | lld:pubmed |
| pubmed-article:7747571 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7747571 | pubmed:articleTitle | Probenecid inhibition of the outward transport of fluorescein across the human blood-retina barrier. | lld:pubmed |
| pubmed-article:7747571 | pubmed:affiliation | Department of Ophthalmology, Gentofte Hospital, University of Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:7747571 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7747571 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7747571 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:7747571 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7747571 | lld:pubmed |
