| pubmed-article:7737424 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C0812204 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C1417616 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C1150423 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C1546856 | lld:lifeskim |
| pubmed-article:7737424 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:7737424 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7737424 | pubmed:dateCreated | 1995-6-8 | lld:pubmed |
| pubmed-article:7737424 | pubmed:abstractText | We recently identified a differentiation inhibiting factor (I-factor) in mouse myeloid leukemia M1 cells as a murine homolog of nm23-H2/nucleoside diphosphate kinase (NDPK)-B gene product. We examined the I-factor activities of several authentic nm23/NDPK proteins, i.e. recombinant rat NDPK alpha and beta, recombinant mouse nm23-M1 and -M2, and recombinant human nm23-H1 and -H2 containing a mutant nm23-H2His protein lacing NDPK activity. Almost all these nm23/NDPK proteins showed I-factor activity. Moreover, to understand the active domain exhibiting I-factor activity of nm23-H2 protein lacking NDPK activity, we have investigated the I-factor activities of some truncated nm23-H2 proteins. The truncated nm23-H2 protein containing N-terminal peptide 1-60 retained the I-factor activity. These results provide the first evidence for a function of nm23/NDPK as a differentiation inhibiting factor in leukemic cells, that is independent of its NDPK activity and dependent on the presence of N-terminal peptide. | lld:pubmed |
| pubmed-article:7737424 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7737424 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7737424 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7737424 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7737424 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7737424 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:ShikuHH | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:HonmaYY | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:HozumiMM | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:KasukabeTT | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:KimuraNN | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:UranoTT | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:BabaHH | lld:pubmed |
| pubmed-article:7737424 | pubmed:author | pubmed-author:Okabe-KadoJJ | lld:pubmed |
| pubmed-article:7737424 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7737424 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:7737424 | pubmed:volume | 363 | lld:pubmed |
| pubmed-article:7737424 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7737424 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7737424 | pubmed:pagination | 311-5 | lld:pubmed |
| pubmed-article:7737424 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7737424 | pubmed:meshHeading | pubmed-meshheading:7737424-... | lld:pubmed |
| pubmed-article:7737424 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7737424 | pubmed:articleTitle | A new function of Nm23/NDP kinase as a differentiation inhibitory factor, which does not require it's kinase activity. | lld:pubmed |
| pubmed-article:7737424 | pubmed:affiliation | Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan. | lld:pubmed |
| pubmed-article:7737424 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7737424 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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