| pubmed-article:7729879 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7729879 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:7729879 | lifeskim:mentions | umls-concept:C0079488 | lld:lifeskim |
| pubmed-article:7729879 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:7729879 | lifeskim:mentions | umls-concept:C2246068 | lld:lifeskim |
| pubmed-article:7729879 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7729879 | pubmed:dateCreated | 1995-6-1 | lld:pubmed |
| pubmed-article:7729879 | pubmed:abstractText | Following exposure to Helicobacter pylori cells, epithelial cell lines secreted interleukin-6 (IL-6) and IL-8 but not tumor necrosis factor alpha. Purified IL-6 alone did not stimulate IL-8 production from the cell lines tested, indicating that IL-6 was not an intermediary in IL-8 induction. Enhanced IL-8 secretion occurred in a time- and dose-dependent manner. None of 12 antibiotics tested exhibited a significant effect on IL-8-inducing activity, suggesting that preformed antigens were responsible for stimulating IL-8 secretion in vitro. Live bacterial cells caused the highest level of stimulation. Proteinase-digested and heated (56 or 100 degrees C) cells had significantly reduced stimulatory activities. Purified H. pylori lipopolysaccharide, but not exopolysaccharide, stimulated low-level secretion of IL-8, but only at high concentrations, while a water-extracted H. pylori antigen preparation was strongly stimulatory for HEp-2 cells. No reduction in IL-8-stimulatory activity was observed for H. pylori mutants negative for urease activity, production of a major lipoprotein, and motility. The noncytotoxic strain CCUG 915 stimulated lower IL-8 levels than other isolates. However, the otherwise isogenic cytotoxin-negative mutant 17874 delta vacA (S. H. Phadnis, D. Ilver, L. Janzon, S. Normark, and T. U. Westblom, Infect. Immun. 62:1557-1565, 1994) had the same IL-8-stimulatory ability as the parent strain, suggesting that surface proteins other than the vacuolating cytotoxin are involved in IL-8 stimulation. | lld:pubmed |
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| pubmed-article:7729879 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7729879 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729879 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7729879 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7729879 | pubmed:month | May | lld:pubmed |
| pubmed-article:7729879 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:7729879 | pubmed:author | pubmed-author:TrustT JTJ | lld:pubmed |
| pubmed-article:7729879 | pubmed:author | pubmed-author:HuangJJ | lld:pubmed |
| pubmed-article:7729879 | pubmed:author | pubmed-author:DoigPP | lld:pubmed |
| pubmed-article:7729879 | pubmed:author | pubmed-author:O'TooleP WPW | lld:pubmed |
| pubmed-article:7729879 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7729879 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:7729879 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7729879 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7729879 | pubmed:pagination | 1732-8 | lld:pubmed |
| pubmed-article:7729879 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7729879 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7729879 | pubmed:articleTitle | Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori. | lld:pubmed |
| pubmed-article:7729879 | pubmed:affiliation | Canadian Bacterial Diseases Network, University of Victoria, British Columbia. | lld:pubmed |
| pubmed-article:7729879 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7729879 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7729879 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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