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pubmed-article:7729539pubmed:abstractTextEndothelin may play a role in atherosclerosis as it causes smooth muscle cell proliferation and its levels are elevated in patients with atherosclerosis. We report that interleukin-1 beta is a potent inducer of endothelin receptor expression in cultured human vascular smooth muscle cells. The effect is dose- and time-dependent and is due to an increase in receptor number. Endothelin receptor mRNA levels are also elevated. Interleukin-1 beta is a major regulator of endothelin release so, together with its effects on endothelin receptors, it may be responsible for a generalized activation of the endothelin system in diseased vessels.lld:pubmed
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pubmed-article:7729539pubmed:articleTitleModulation of endothelin receptor expression in human vascular smooth muscle cells by interleukin-1 beta.lld:pubmed
pubmed-article:7729539pubmed:affiliationThrombosis Research Institute, London, UK.lld:pubmed
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