| pubmed-article:7727767 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0025927 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C1253959 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0017963 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0080096 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C0205280 | lld:lifeskim |
| pubmed-article:7727767 | lifeskim:mentions | umls-concept:C1321758 | lld:lifeskim |
| pubmed-article:7727767 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7727767 | pubmed:dateCreated | 1995-5-31 | lld:pubmed |
| pubmed-article:7727767 | pubmed:abstractText | Interleukin-3 (IL-3) stimulates colony formation of multiple lineages of hematopoietic cells. Bone marrow cells of A/J mice are nonresponsive to IL-3, and this observation has recently been correlated with aberrant mRNA splicing and impaired expression of the IL-3 receptor alpha subunit (IL-3R alpha), a binding component of the high-affinity receptors. We examined the IL-3R alpha gene in 27 inbred mouse strains and found the identical mutation, a 5-bp deletion at the branch point of intron 7, in 10 of these mouse strains. Bone marrow cells isolated from these 10 mouse strains did not express IL-3R alpha on the cell surface and did not form colonies in response to IL-3. Because the defective IL-3R alpha gene was found in several distantly related mouse strains, it appears to be a recessive allele rather than a sporadic mutation. In contrast, only 1 of 21 wild-derived mouse strains carried the 5-bp deletion in the IL-3R alpha gene. This study suggests that IL-3 function is not required for normal hematopoiesis in mice, but the retention of the IL-3 and IL-3R system may be of some selective advantage in wild populations. | lld:pubmed |
| pubmed-article:7727767 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7727767 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727767 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7727767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727767 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727767 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7727767 | pubmed:month | May | lld:pubmed |
| pubmed-article:7727767 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7727767 | pubmed:author | pubmed-author:HaraTT | lld:pubmed |
| pubmed-article:7727767 | pubmed:author | pubmed-author:TakagiMM | lld:pubmed |
| pubmed-article:7727767 | pubmed:author | pubmed-author:IchiharaMM | lld:pubmed |
| pubmed-article:7727767 | pubmed:author | pubmed-author:MiyajimaAA | lld:pubmed |
| pubmed-article:7727767 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7727767 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7727767 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:7727767 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7727767 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7727767 | pubmed:pagination | 2331-6 | lld:pubmed |
| pubmed-article:7727767 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7727767 | pubmed:meshHeading | pubmed-meshheading:7727767-... | lld:pubmed |
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| pubmed-article:7727767 | pubmed:meshHeading | pubmed-meshheading:7727767-... | lld:pubmed |
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| pubmed-article:7727767 | pubmed:meshHeading | pubmed-meshheading:7727767-... | lld:pubmed |
| pubmed-article:7727767 | pubmed:meshHeading | pubmed-meshheading:7727767-... | lld:pubmed |
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| pubmed-article:7727767 | pubmed:meshHeading | pubmed-meshheading:7727767-... | lld:pubmed |
| pubmed-article:7727767 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7727767 | pubmed:articleTitle | Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. | lld:pubmed |
| pubmed-article:7727767 | pubmed:affiliation | Department of Cell Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA. | lld:pubmed |
| pubmed-article:7727767 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7727767 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7727767 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16188 | entrezgene:pubmed | pubmed-article:7727767 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7727767 | lld:pubmed |
