| pubmed-article:7726912 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C0019904 | lld:lifeskim |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C0281361 | lld:lifeskim |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C0525037 | lld:lifeskim |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C0544886 | lld:lifeskim |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:7726912 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:7726912 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7726912 | pubmed:dateCreated | 1995-1-6 | lld:pubmed |
| pubmed-article:7726912 | pubmed:abstractText | The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions of 9p21-p22 in 85% of pancreatic adenocarcinomas. Analysis of MTS1 in pancreatic carcinomas (27 xenografts and 10 cell lines) showed homozygous deletions in 15 (41%) and sequence changes in 14 (38%). These included eight point mutations (four nonsense, two missense and two splice site mutations) and six deletions/insertions, all accompanied by loss of the wild-type allele. Sequencing of MTS1 from primary tumours confirmed the mutations. Coexistent inactivations of both MTS1 and p53 was common and suggests that abnormal regulation of cyclin-dependent kinases may play an important role in the biology of pancreatic carcinoma. | lld:pubmed |
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| pubmed-article:7726912 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726912 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7726912 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726912 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7726912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726912 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726912 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7726912 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7726912 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:SchutteMM | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:KerrS ASA | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:YeoC JCJ | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:HrubanR HRH | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:CaldasCC | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:WeinsteinC... | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:da CostaL TLT | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:HahnS ASA | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:SeymourA BAB | lld:pubmed |
| pubmed-article:7726912 | pubmed:author | pubmed-author:RedstonM SMS | lld:pubmed |
| pubmed-article:7726912 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7726912 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:7726912 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7726912 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7726912 | pubmed:pagination | 27-32 | lld:pubmed |
| pubmed-article:7726912 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7726912 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7726912 | pubmed:articleTitle | Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. | lld:pubmed |
| pubmed-article:7726912 | pubmed:affiliation | Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205. | lld:pubmed |
| pubmed-article:7726912 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7726912 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7726912 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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