| pubmed-article:7726827 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7726827 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7726827 | lifeskim:mentions | umls-concept:C0085080 | lld:lifeskim |
| pubmed-article:7726827 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:7726827 | lifeskim:mentions | umls-concept:C0073337 | lld:lifeskim |
| pubmed-article:7726827 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7726827 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7726827 | pubmed:dateCreated | 1995-5-25 | lld:pubmed |
| pubmed-article:7726827 | pubmed:abstractText | We investigated epidermal growth factor (EGF)-induced activation of 85-kDa/110-kDa phosphatidylinositol (PI)-3-kinase and 70-kDa S6 kinase in Chinese hamster ovary cells expressing the human EGF receptor. EGF-induced activation of p70 S6 kinase was comparable to that induced by insulin, whereas that of PI-3-kinase in anti-phosphotyrosine immunoprecipitates was very small compared with insulin. Wortmannin, a p85/p110 PI-3-kinase inhibitor, inhibited EGF-induced activation of p70 S6 kinase in a dose-dependent manner. Given that several proteins homologous to catalytic subunit of p85/p110 PI-3-kinase have been identified and that wortmannin inhibits distinct form of PI-3-kinase, the present results suggest that wortmannin-sensitive kinases that resemble catalytic subunit of p85/p110 PI-3-kinase may participate in the signaling pathway from EGF receptors to p70 S6 kinase. | lld:pubmed |
| pubmed-article:7726827 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7726827 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726827 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7726827 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7726827 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7726827 | pubmed:author | pubmed-author:SakaguchiKK | lld:pubmed |
| pubmed-article:7726827 | pubmed:author | pubmed-author:SugimotoYY | lld:pubmed |
| pubmed-article:7726827 | pubmed:author | pubmed-author:KidoYY | lld:pubmed |
| pubmed-article:7726827 | pubmed:author | pubmed-author:KasugaMM | lld:pubmed |
| pubmed-article:7726827 | pubmed:author | pubmed-author:OkutaniTT | lld:pubmed |
| pubmed-article:7726827 | pubmed:author | pubmed-author:OkabayashiYY | lld:pubmed |
| pubmed-article:7726827 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7726827 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:7726827 | pubmed:volume | 209 | lld:pubmed |
| pubmed-article:7726827 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7726827 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7726827 | pubmed:pagination | 131-8 | lld:pubmed |
| pubmed-article:7726827 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7726827 | pubmed:meshHeading | pubmed-meshheading:7726827-... | lld:pubmed |
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| pubmed-article:7726827 | pubmed:meshHeading | pubmed-meshheading:7726827-... | lld:pubmed |
| pubmed-article:7726827 | pubmed:meshHeading | pubmed-meshheading:7726827-... | lld:pubmed |
| pubmed-article:7726827 | pubmed:meshHeading | pubmed-meshheading:7726827-... | lld:pubmed |
| pubmed-article:7726827 | pubmed:meshHeading | pubmed-meshheading:7726827-... | lld:pubmed |
| pubmed-article:7726827 | pubmed:meshHeading | pubmed-meshheading:7726827-... | lld:pubmed |
| pubmed-article:7726827 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7726827 | pubmed:articleTitle | EGF-induced activation of 70-kDa S6 kinase in CHO cells expressing human EGF receptors. | lld:pubmed |
| pubmed-article:7726827 | pubmed:affiliation | Second Department of Internal Medicine, Kobe University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:7726827 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7726827 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7726827 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7726827 | lld:pubmed |
