| pubmed-article:7726496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0085484 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C1167331 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0020933 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0597979 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0066005 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0205345 | lld:lifeskim |
| pubmed-article:7726496 | lifeskim:mentions | umls-concept:C0007605 | lld:lifeskim |
| pubmed-article:7726496 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7726496 | pubmed:dateCreated | 1995-5-23 | lld:pubmed |
| pubmed-article:7726496 | pubmed:abstractText | The roles of outer membrane permeability and Bush group 1 beta-lactamase activity in determining Enterobacter cloacae susceptibility to either meropenem or imipenem were investigated. A beta-lactamase-deficient strain was obtained by mutagenesis from a clinical isolate of E. cloacae, and a porin-deficient strain was selected from this mutant with cefoxitin. Both strains were transformed with the plasmid pAA20R, which contained the gene coding for the carbapenem-hydrolyzing CphA beta-lactamase, and the carbapenem permeability coefficients were measured by the Zimmermann and Rosselet technique (W. Zimmermann and A. Rosselet, Antimicrob. Agents Chemother. 12:368-372, 1977). The permeability coefficient of meropenem was roughly half that of imipenem in the normally permeable strain and almost seven times lower than that of imipenem in the porin-deficient strain. In the porin-deficient strain, the virtual absence of porins caused the MICs of meropenem to increase from 8 to 16 times, while it did not affect the MICs of imipenem. Conversely, the beta-lactamase affected imipenem but not meropenem activity: meropenem showed a similar activity in the parent strain and in the beta-lactamase-deficient mutant with both a low- and high-density inoculum, whereas imipenem was 16 times less active against the parent strain when the high-density inoculum was used. It is concluded that outer membrane permeability and stability to group 1 beta-lactamase have different impacts on the activities of meropenem and imipenem against E. cloacae. | lld:pubmed |
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| pubmed-article:7726496 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7726496 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7726496 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7726496 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7726496 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7726496 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:7726496 | pubmed:author | pubmed-author:SattaGG | lld:pubmed |
| pubmed-article:7726496 | pubmed:author | pubmed-author:FontanaRR | lld:pubmed |
| pubmed-article:7726496 | pubmed:author | pubmed-author:RussellKK | lld:pubmed |
| pubmed-article:7726496 | pubmed:author | pubmed-author:CornagliaGG | lld:pubmed |
| pubmed-article:7726496 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7726496 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:7726496 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7726496 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7726496 | pubmed:pagination | 350-5 | lld:pubmed |
| pubmed-article:7726496 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7726496 | pubmed:meshHeading | pubmed-meshheading:7726496-... | lld:pubmed |
| pubmed-article:7726496 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7726496 | pubmed:articleTitle | Relative importances of outer membrane permeability and group 1 beta-lactamase as determinants of meropenem and imipenem activities against Enterobacter cloacae. | lld:pubmed |
| pubmed-article:7726496 | pubmed:affiliation | Università degli Studi di Verona, Istituto di Microbiologia, Verona, Italy. | lld:pubmed |
| pubmed-article:7726496 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7726496 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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