| pubmed-article:7724606 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C0035366 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C0017278 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1422036 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:7724606 | lifeskim:mentions | umls-concept:C0597551 | lld:lifeskim |
| pubmed-article:7724606 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7724606 | pubmed:dateCreated | 1995-5-25 | lld:pubmed |
| pubmed-article:7724606 | pubmed:abstractText | The influence of a synthetic retroviral peptide, CKS-17, on T helper type 1 (Th1)- or Th2-related cytokines was investigated in human blood mononuclear cells. Cells were stimulated with staphylococcal enterotoxin A, anti-CD3 plus anti-CD28 monoclonal antibodies, or lipopolysaccharide to induce cytokine mRNA. mRNA was detected by a reverse transcription-polymerase chain reaction or Northern blot analysis. CKS-17 down-regulated stimulant-induced mRNA accumulation for interferon gamma (IFN-gamma), interleukin (IL)-2, and p40 heavy and p35 light chains of IL-12, a cytokine that mediates development of Th1 response. CKS-17 up-regulated stimulant-induced mRNA accumulation of IL-10 and did not suppress Th2-related cytokine (IL-4, IL-5, IL-6, or IL-13) mRNA expression. A reverse sequence of CKS-17 peptide, used as a control, showed no such action. Anti-human IL-10 monoclonal antibody blocked ability of CKS-17 to inhibit mRNA accumulation for IFN-gamma but not the CKS-17 suppressive activity of IL-12 p40 heavy chain mRNA. Thus, CKS-17-mediated suppression of IFN-gamma mRNA expression is dependent upon augmentation of IL-10 production by CKS-17. This conserved component of several retroviral envelope proteins, CKS-17, may act as an immunomodulatory epitope responsible for cytokine dysregulation that leads to suppression of cellular immunity. | lld:pubmed |
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| pubmed-article:7724606 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7724606 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7724606 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7724606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7724606 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7724606 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7724606 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7724606 | pubmed:author | pubmed-author:GoodR ARA | lld:pubmed |
| pubmed-article:7724606 | pubmed:author | pubmed-author:CiancioloG... | lld:pubmed |
| pubmed-article:7724606 | pubmed:author | pubmed-author:DayN KNK | lld:pubmed |
| pubmed-article:7724606 | pubmed:author | pubmed-author:HaraguchiSS | lld:pubmed |
| pubmed-article:7724606 | pubmed:author | pubmed-author:James-YarishM... | lld:pubmed |
| pubmed-article:7724606 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7724606 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:7724606 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7724606 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7724606 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7724606 | pubmed:pagination | 3611-5 | lld:pubmed |
| pubmed-article:7724606 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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