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pubmed-article:7724493pubmed:dateCreated1995-5-23lld:pubmed
pubmed-article:7724493pubmed:abstractTextA new method for estimating dermal absorption including the effects of exposure time and chemistry is described generally in Part 1 of this series. This method accounts for the larger absorption rates during the initial exposure period as well as the hydrophilic barrier which the viable epidermis presents to lipophilic chemicals. A key parameter in this procedure, the ratio of the stratum corneum and epidermis permeabilities (B) depends on molecular weight and octanol-water partitioning. Several approaches for approximating B and its affect on the dermal absorption prediction are discussed here. Generally, the parameter B is only important for highly lipophilic chemicals which also have relatively small molecular weights. When B is important, the recommended prediction for B is based on the Potts and Guy correlation for human stratum corneum permeability.lld:pubmed
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pubmed-article:7724493pubmed:authorpubmed-author:BungeA LALlld:pubmed
pubmed-article:7724493pubmed:authorpubmed-author:CleekR LRLlld:pubmed
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pubmed-article:7724493pubmed:volume12lld:pubmed
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pubmed-article:7724493pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:7724493pubmed:year1995lld:pubmed
pubmed-article:7724493pubmed:articleTitleA new method for estimating dermal absorption from chemical exposure: 2. Effect of molecular weight and octanol-water partitioning.lld:pubmed
pubmed-article:7724493pubmed:affiliationChemical Engineering and Petroleum Refining Department, Colorado School of Mines, Golden 80401, USA.lld:pubmed
pubmed-article:7724493pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7724493pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed