| pubmed-article:7721443 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0068980 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0232970 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C1384115 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0699857 | lld:lifeskim |
| pubmed-article:7721443 | lifeskim:mentions | umls-concept:C0016441 | lld:lifeskim |
| pubmed-article:7721443 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:7721443 | pubmed:dateCreated | 1995-5-25 | lld:pubmed |
| pubmed-article:7721443 | pubmed:abstractText | Postmenopausal women (PMW) have an increased risk of cardiovascular disease that is attenuated by hormone replacement therapy (HRT). Inasmuch as hypertension and atherosclerosis are associated with diminished endothelium-derived nitric oxide (NO), we investigated whether HRT augments NO release in PMW. We determined serum levels of nitrite/nitrate (NO2 + NO3) at baseline and during the 6th, 12th, and 24th months of the study in two groups of PMW. One group (HRT-PMW, n = 13) received continuous transdermal administration of 17 beta-estradiol (Estraderm-TTS-50) supplemented with oral norethisterone acetate (NETA) on days 1 through 12 of each month, and the other group (control PMW, n = 13) did not receive HRT. Blood samples in the HRT-PMW group were collected without regard to whether subjects were taking NETA at the time of blood sampling. Serum NO2 + NO3 levels increased in HRT-PMW for the duration of the study, whereas serum NO2 + NO3 levels remained unchanged in control PMW. When all samples regardless of timing of collection with respect to NETA treatment were included in the statistical analysis, the change in NO2 + NO3 levels in HRT-PMW was significantly greater compared with the change in control PMW (P = .037). Likewise, when only those samples collected when estradiol-treated subjects were not taking oral NETA were included in the statistical analysis, the change in NO2 + NO3 levels in the HRT-PMW group remained significant (P = .047) compared with control PMW.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7721443 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7721443 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7721443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7721443 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7721443 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7721443 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:7721443 | pubmed:author | pubmed-author:KellerP JPJ | lld:pubmed |
| pubmed-article:7721443 | pubmed:author | pubmed-author:JacksonE KEK | lld:pubmed |
| pubmed-article:7721443 | pubmed:author | pubmed-author:RosselliMM | lld:pubmed |
| pubmed-article:7721443 | pubmed:author | pubmed-author:DubeyR KRK | lld:pubmed |
| pubmed-article:7721443 | pubmed:author | pubmed-author:ImthurnBB | lld:pubmed |
| pubmed-article:7721443 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7721443 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7721443 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7721443 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7721443 | pubmed:pagination | 848-53 | lld:pubmed |
| pubmed-article:7721443 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:meshHeading | pubmed-meshheading:7721443-... | lld:pubmed |
| pubmed-article:7721443 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7721443 | pubmed:articleTitle | Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 beta-estradiol and norethisterone acetate. A two-year follow-up study. | lld:pubmed |
| pubmed-article:7721443 | pubmed:affiliation | Department of Obstetrics and Gynecology, Clinic of Endocrinology, University Hospital, Zurich, Switzerland. | lld:pubmed |
| pubmed-article:7721443 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7721443 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7721443 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7721443 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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