| pubmed-article:7719150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0014072 | lld:lifeskim |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:7719150 | lifeskim:mentions | umls-concept:C0001758 | lld:lifeskim |
| pubmed-article:7719150 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7719150 | pubmed:dateCreated | 1995-5-22 | lld:pubmed |
| pubmed-article:7719150 | pubmed:abstractText | We investigated the in vitro adhesion of 51Cr-labeled lymphocytes to cultured brain endothelial cells and the in vivo expression of intercellular adhesion molecule-1 (ICAM-1) on cerebral endothelial cells in a rat model of experimental allergic encephalomyelitis (EAE) before and after treatment with lipopolysaccharide (LPS). Adhesion of lymphocytes to cerebral endothelial cells was significantly increased in EAE compared with controls (p < 0.01), and was significantly correlated with the percentage of major histocompatibility complex class II antigen-positive cells in lymph node cells (p < 0.001). LPS enhanced ICAM-1 expression on endothelial cells and lymphocyte adhesion to those cells, and caused a significant increase in the in vivo expression of ICAM-1 compared with controls (p < 0.001). Lymphocyte adhesion to endothelial cells was significantly blocked by monoclonal antibodies against ICAM-1, lymphocyte function-associated antigen-1, or very late activation antigen-4. Our findings suggest that lymphocyte adhesion to brain endothelial cells may contribute to lymphocyte migration across the blood-brain barrier in EAE and that LPS may cause progression of EAE lesions. | lld:pubmed |
| pubmed-article:7719150 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7719150 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7719150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7719150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7719150 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7719150 | pubmed:issn | 1018-2438 | lld:pubmed |
| pubmed-article:7719150 | pubmed:author | pubmed-author:MatsudaMM | lld:pubmed |
| pubmed-article:7719150 | pubmed:author | pubmed-author:YanagisawaNN | lld:pubmed |
| pubmed-article:7719150 | pubmed:author | pubmed-author:MiyagiKK | lld:pubmed |
| pubmed-article:7719150 | pubmed:author | pubmed-author:TsukadaNN | lld:pubmed |
| pubmed-article:7719150 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7719150 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:7719150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7719150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7719150 | pubmed:pagination | 335-44 | lld:pubmed |
| pubmed-article:7719150 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:meshHeading | pubmed-meshheading:7719150-... | lld:pubmed |
| pubmed-article:7719150 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7719150 | pubmed:articleTitle | Adhesion of lymphocytes to endothelial cells in experimental allergic encephalomyelitis before and after treatment with endotoxin lipopolysaccharide. | lld:pubmed |
| pubmed-article:7719150 | pubmed:affiliation | Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan. | lld:pubmed |
| pubmed-article:7719150 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7719150 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
