| pubmed-article:7714809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0023951 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7714809 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7714809 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7714809 | pubmed:dateCreated | 1995-5-17 | lld:pubmed |
| pubmed-article:7714809 | pubmed:abstractText | The effect of adenosine on locus ceruleus neurons was investigated with intracellular recording in a totally submerged brain slice preparation. Bath application of adenosine (100 microM) hyperpolarized locus ceruleus neurons and inhibited their spontaneous firing; under voltage-clamp conditions, adenosine activated an inwardly rectifying, outward current (IAdo). The reversal potential of the IAdo was -110 mV and shifted by 59.2 mV per 10-fold change in external K+ concentration, very close to the shift predicted by the Nernst equation for a pure K+ current. The IAdo was due to a direct postsynaptic action, because it persisted in low Ca++/high Mg++ media that block Ca(++)-dependent neurotransmitter release. The IAdo was not blocked by glibenclamide, which indicates that it is not mediated by ATP-dependent K+ channels. The adenosine-activated current was concentration-dependent (10 microM-1 mM adenosine) and was blocked by the selective A1 antagonist 8-cyclopentyltheophylline in a competitive manner. Schild analysis in two neurons yielded estimates of the Kd value for 8-cyclopentyltheophylline of 1.4 and 4.6 nM, which indicates that the IAdo is mediated by A1 adenosine receptors. The adenosine-induced hyperpolarization, inhibition of firing and activation of outward current were blocked by external barium, but not by 4-aminopyridine. By contrast, we have previously shown that adenosine enhances A-current, thereby reducing action potential duration in locus ceruleus neurons, and these effects are blocked by 4-aminopyridine but not barium. These data indicate that the adenosine-induced hyperpolarization and inhibition of firing are mediated by the IAdo and that these effects are independent of adenosine's enhancement of A-current. | lld:pubmed |
| pubmed-article:7714809 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7714809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714809 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7714809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7714809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7714809 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7714809 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:7714809 | pubmed:author | pubmed-author:PanW JWJ | lld:pubmed |
| pubmed-article:7714809 | pubmed:author | pubmed-author:ShefnerS ASA | lld:pubmed |
| pubmed-article:7714809 | pubmed:author | pubmed-author:Osmanovi?S... | lld:pubmed |
| pubmed-article:7714809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7714809 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:7714809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7714809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7714809 | pubmed:pagination | 537-44 | lld:pubmed |
| pubmed-article:7714809 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7714809 | pubmed:meshHeading | pubmed-meshheading:7714809-... | lld:pubmed |
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| pubmed-article:7714809 | pubmed:meshHeading | pubmed-meshheading:7714809-... | lld:pubmed |
| pubmed-article:7714809 | pubmed:meshHeading | pubmed-meshheading:7714809-... | lld:pubmed |
| pubmed-article:7714809 | pubmed:meshHeading | pubmed-meshheading:7714809-... | lld:pubmed |
| pubmed-article:7714809 | pubmed:meshHeading | pubmed-meshheading:7714809-... | lld:pubmed |
| pubmed-article:7714809 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7714809 | pubmed:articleTitle | Characterization of the adenosine A1 receptor-activated potassium current in rat locus ceruleus neurons. | lld:pubmed |
| pubmed-article:7714809 | pubmed:affiliation | Department of Physiology and Biophysics, University of Illinois at Chicago, USA. | lld:pubmed |
| pubmed-article:7714809 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7714809 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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