| pubmed-article:7714103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7714103 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:7714103 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:7714103 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:7714103 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:7714103 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7714103 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7714103 | pubmed:dateCreated | 1995-5-12 | lld:pubmed |
| pubmed-article:7714103 | pubmed:abstractText | Galactosyl-hydroxylysine (Gal-Hyl) is the predominant product of the posttranslational glycosylation of skeletal collagen. Urinary Gal-Hyl excretion is regarded as a marker of bone resorption in adults, but little information is available on the validity of this parameter in pediatric age groups. Using 24-h urine samples from 88 healthy children and adolescents ages 4-18 yr, reference ranges were established for this age group, and values were compared with measurements in children with overt GH deficiency (n = 14) or Ullrich-Turner syndrome (n = 21). When expressed relative to body weight (Gal-Hyl/wt), urinary Gal-Hyl excretion was 3.2 to 4.7 times higher in subjects 4-16 yr of age than in adults. Highest values were observed in very young children and during the pubertal growth spurt. In the total population, urinary Gal-Hyl/wt was closely related to growth velocity (r = 0.72) and significantly correlated with the urinary excretion of both hydroxyproline (r = 0.74) and deoxypyridinoline (r = 0.88; P < 0.001 each). Urinary Gal-Hyl/wt was significantly lower in children with GH deficiency or Ullrich-Turner syndrome than in healthy children (P < 0.001 each). The urinary excretion of Gal-Hyl was significantly correlated with growth velocity in GH-deficient children (r = 0.69; P = 0.004) but not in patients with Ullrich-Turner syndrome. In the latter, the increase in urinary Gal-Hyl excretion after 3 months of treatment with recombinant human GH correlated significantly with the increase in growth velocity after 12 months of treatment (r = 0.76; P = 0.002). We conclude that the urinary excretion of Gal-Hyl is a valid and potentially useful index of skeletal growth in children. | lld:pubmed |
| pubmed-article:7714103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7714103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7714103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7714103 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7714103 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:MichalkDD | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:SeibelM JMJ | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:SchnabelDD | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:SchönauEE | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:RemerTT | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:RauchFF | lld:pubmed |
| pubmed-article:7714103 | pubmed:author | pubmed-author:StabreyAA | lld:pubmed |
| pubmed-article:7714103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7714103 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:7714103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7714103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7714103 | pubmed:pagination | 1295-300 | lld:pubmed |
| pubmed-article:7714103 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7714103 | pubmed:meshHeading | pubmed-meshheading:7714103-... | lld:pubmed |
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| pubmed-article:7714103 | pubmed:meshHeading | pubmed-meshheading:7714103-... | lld:pubmed |
| pubmed-article:7714103 | pubmed:meshHeading | pubmed-meshheading:7714103-... | lld:pubmed |
| pubmed-article:7714103 | pubmed:meshHeading | pubmed-meshheading:7714103-... | lld:pubmed |
| pubmed-article:7714103 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7714103 | pubmed:articleTitle | Urinary excretion of galactosyl-hydroxylysine is a marker of growth in children. | lld:pubmed |
| pubmed-article:7714103 | pubmed:affiliation | Childrens' Hospital, University of Cologne, Germany. | lld:pubmed |
| pubmed-article:7714103 | pubmed:publicationType | Journal Article | lld:pubmed |
