| pubmed-article:7713162 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7713162 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:7713162 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7713162 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:7713162 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:7713162 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:7713162 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:7713162 | pubmed:dateCreated | 1995-5-12 | lld:pubmed |
| pubmed-article:7713162 | pubmed:abstractText | The pharmacological modulation of the accumulation and function of eosinophils in tissues may have a significant impact in the treatment of allergic diseases such as asthma, atopic dermatitis and rhinitis. In this study, we have investigated the acute anti-inflammatory effects of a short-acting (salbutamol) and a long-acting (salmeterol) beta 2-adrenoceptor agonist on 111In-accumulation and oedema formation in allergic and mediator-induced inflammation in guinea pig skin. Both salbutamol and salmeterol inhibited 111In-eosinophil accumulation induced by platelet-activating factor and in a passive cutaneous anaphylactic reaction when co-injected with the inflammatory stimuli or when given as a 30 min pretreatment. The inhibition was reversed by DL-propranolol, but not D-propranolol. Systemic treatment with salbutamol inhibited 111In-eosinophil accumulation and oedema formation when given as a 15 min, but not as a 3 h, pretreatment. In contrast, salmeterol was effective when given at both times. We conclude that a long duration of action of beta 2-adrenoceptor agonists is not necessary to demonstrate acute anti-inflammatory effects on eosinophil accumulation in guinea pig skin. | lld:pubmed |
| pubmed-article:7713162 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7713162 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7713162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7713162 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7713162 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7713162 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7713162 | pubmed:author | pubmed-author:WilliamsT JTJ | lld:pubmed |
| pubmed-article:7713162 | pubmed:author | pubmed-author:HellewellP... | lld:pubmed |
| pubmed-article:7713162 | pubmed:author | pubmed-author:TeixeiraM MMM | lld:pubmed |
| pubmed-article:7713162 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7713162 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:7713162 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:7713162 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7713162 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7713162 | pubmed:pagination | 185-93 | lld:pubmed |
| pubmed-article:7713162 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:meshHeading | pubmed-meshheading:7713162-... | lld:pubmed |
| pubmed-article:7713162 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7713162 | pubmed:articleTitle | Anti-inflammatory effects of a short-acting and a long-acting beta 2-adrenoceptor agonist in guinea pig skin. | lld:pubmed |
| pubmed-article:7713162 | pubmed:affiliation | Department of Applied Pharmacology, National Heart and Lung Institute, London, UK. | lld:pubmed |
| pubmed-article:7713162 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7713162 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7713162 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7713162 | lld:pubmed |
