| pubmed-article:7709867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0016085 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0680063 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C1858460 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0162615 | lld:lifeskim |
| pubmed-article:7709867 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7709867 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:7709867 | pubmed:dateCreated | 1995-5-10 | lld:pubmed |
| pubmed-article:7709867 | pubmed:abstractText | We have used the severe combined immunodeficient C.B-17-scid/scid mouse to investigate the influences of maternal immune status and parasite burden on the susceptibility (or resistance) of offspring to infection with the human filarial parasite, Brugia malayi. C.B-17-scid/scid mice are permissive for infection while immunocompetent C.B-17(-)+/+ mice are uniformly resistant. Reciprocal matings of C.B-17-scid/scid and C.B-17(-)+/+ mice were performed. The C.B-17-scid/scid females were either naive or infected with Brugia malayi. The resulting immunocompetent C.B-17-scid/+ and C.B-17(-)+/scid progeny were challenged at weaning with an intraperitoneal injection of Brugia malayi third stage larvae known to produce patent infection in > 95% of C.B-17-scid/scid mice. We observed that 40.0%l (34/85) of the immunocompetent offspring of C.B-17-scid/scid females x C.B-17(-)+/+ males were permissive for the growth and development of Brugia malayi larvae to adults. No difference was observed in susceptibility to infection between the progeny of infected or uninfected C.B-17-scid/scid mothers mated with C.B-17(-)+/+ fathers, arguing against acquired immunological tolerance to the parasite in the former. In marked contrast, only 4.8% (2/42) of the heterozygous progeny of wild type C.B-17(-)+/+ females mated with C.B-17-scid/scid males were permissive. These observations document conversion of a 'resistant' phenotype to a 'susceptible' phenotype by manipulation of maternal immune status and provide clear evidence of maternal influence on offspring susceptibility to infection with Brugia malayi. | lld:pubmed |
| pubmed-article:7709867 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7709867 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7709867 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7709867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7709867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7709867 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7709867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7709867 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7709867 | pubmed:issn | 0001-706X | lld:pubmed |
| pubmed-article:7709867 | pubmed:author | pubmed-author:GreinerD LDL | lld:pubmed |
| pubmed-article:7709867 | pubmed:author | pubmed-author:ShultzL DLD | lld:pubmed |
| pubmed-article:7709867 | pubmed:author | pubmed-author:RajanT VTV | lld:pubmed |
| pubmed-article:7709867 | pubmed:author | pubmed-author:NelsonF KFK | lld:pubmed |
| pubmed-article:7709867 | pubmed:author | pubmed-author:YatesJ AJA | lld:pubmed |
| pubmed-article:7709867 | pubmed:author | pubmed-author:BailitJ LJL | lld:pubmed |
| pubmed-article:7709867 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7709867 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:7709867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7709867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7709867 | pubmed:pagination | 283-9 | lld:pubmed |
| pubmed-article:7709867 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:meshHeading | pubmed-meshheading:7709867-... | lld:pubmed |
| pubmed-article:7709867 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7709867 | pubmed:articleTitle | Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis. | lld:pubmed |
| pubmed-article:7709867 | pubmed:affiliation | Department of Pathology, University of Connecticut Health Center, Farmington 06030. | lld:pubmed |
| pubmed-article:7709867 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7709867 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
