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pubmed-article:7707195pubmed:abstractTextHerein we report the development of a canine model to examine transplacental and/or transmammary transmission of Neospora caninum. Six pregnant bitches were experimentally infected with N. caninum on day 21 of gestation. One bitch successfully delivered a litter of 3 live pups. These pups showed slight proprioception deficits, increased muscle tone, and spasticity in both pelvic limbs; however, N. caninum was neither demonstrated by bioassay in cell culture nor seen in histological sections of tissues from these pups. The remaining 5 bitches aborted. Neospora caninum was isolated from tissues of 4 of the experimentally infected bitches and pups from 2 of the miscarried litters. Experimental infections of 2 litters of 5-day-old nursing pups produced variable results. Neospora caninum was isolated from 2 of 2 inoculated pups in 1 litter and 3 of 6 inoculated pups in the second litter.lld:pubmed
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pubmed-article:7707195pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:7707195pubmed:year1995lld:pubmed
pubmed-article:7707195pubmed:articleTitleVertical transmission of Neospora caninum in dogs.lld:pubmed
pubmed-article:7707195pubmed:affiliationDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849, USA.lld:pubmed
pubmed-article:7707195pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7707195pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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