| pubmed-article:7705467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7705467 | lifeskim:mentions | umls-concept:C0033011 | lld:lifeskim |
| pubmed-article:7705467 | lifeskim:mentions | umls-concept:C0042149 | lld:lifeskim |
| pubmed-article:7705467 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:7705467 | lifeskim:mentions | umls-concept:C0356649 | lld:lifeskim |
| pubmed-article:7705467 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:7705467 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7705467 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7705467 | pubmed:dateCreated | 1995-5-10 | lld:pubmed |
| pubmed-article:7705467 | pubmed:abstractText | This study investigated the mechanism of activation of K+ channels by ritodrine hydrochloride in human myometrial smooth muscle cells. The patch-clamp technique was used for recording single channel currents. Ritodrine (10(-5) M) activated two types of K+ channels in cultured uterine smooth muscle cells from pregnant women: the Ca(2+)-activated K+ (KCa) channel and the ATP-sensitive K+ (KATP) channel. Forskolin (10(-4) M), an activator of adenylate cyclase, and protein kinase A activated the KCa channel. In addition, 10(-4) M GTP activated the KCa channel in inside-out patches using a pipette containing 10(-5) M ritodrine. The KATP channel was activated by protein kinase A, but not by 10(-4) M GTP. The beta-adrenoceptor agonist ritodrine activates two types of K+ channels: the KCa channel via direct gating by GTP-binding proteins and possibly via cAMP-dependent phosphorylation, and the KATP channel possibly via cAMP-dependent phosphorylation. These mechanisms partially explain the relaxing effect of ritodrine hydrochloride. | lld:pubmed |
| pubmed-article:7705467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7705467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7705467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7705467 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7705467 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7705467 | pubmed:author | pubmed-author:HamadaSS | lld:pubmed |
| pubmed-article:7705467 | pubmed:author | pubmed-author:NakayaYY | lld:pubmed |
| pubmed-article:7705467 | pubmed:author | pubmed-author:HamadaYY | lld:pubmed |
| pubmed-article:7705467 | pubmed:author | pubmed-author:KamadaMM | lld:pubmed |
| pubmed-article:7705467 | pubmed:author | pubmed-author:AonoTT | lld:pubmed |
| pubmed-article:7705467 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7705467 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7705467 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:7705467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7705467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7705467 | pubmed:pagination | 45-51 | lld:pubmed |
| pubmed-article:7705467 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:meshHeading | pubmed-meshheading:7705467-... | lld:pubmed |
| pubmed-article:7705467 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7705467 | pubmed:articleTitle | Activation of K+ channels by ritodrine hydrochloride in uterine smooth muscle cells from pregnant women. | lld:pubmed |
| pubmed-article:7705467 | pubmed:affiliation | Second Department of Internal Medicine, School of Medicine, University of Tokushima, Japan. | lld:pubmed |
| pubmed-article:7705467 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7705467 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7705467 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7705467 | lld:pubmed |
