| pubmed-article:7705461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C0079284 | lld:lifeskim |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7705461 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7705461 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7705461 | pubmed:dateCreated | 1995-5-10 | lld:pubmed |
| pubmed-article:7705461 | pubmed:abstractText | The activation of signal transduction pathways by endothelin-1 or endothelin-3 were investigated in rat cerebromicrovascular endothelial cells. Endothelin-1 induced a rapid increase in inositol triphosphate (IP3) formation in these cells, whereas endothelin-3 was only moderately effective at high concentrations. Both endothelins also increased uptake of 45Ca2+ in these cells. Endothelin-1-induced IP3 formation or 45Ca2+ uptake were inhibited by endothelin ETA receptor antagonist BQ-123. Ryanodine, an inhibitor of intracellular Ca2+ mobilization, selectively endothelin-1-induced 45Ca2+ uptake, whereas nickel or suramin inhibited endothelin-3-induced 45Ca2+ uptake. The results indicate that endothelin-1 elevates 45Ca2+ uptake in rat brain endothelial cells by mechanisms coupled to the mobilization of intracellular Ca2+ stores. Both endothelin-1- and endothelin-3-induced 45Ca2+ uptake were inhibited by receptor operated Ca2+ channel blocker SK&F 96365, whereas they were insensitive to dihydropyridine derivatives nifedipine and nitrendipine. The release of arachidonic acid from rat brain endothelial cells observed in response to endothelin-1 was inhibited by ryanodine or SK&F 96365, implicating participation of both intra- and extra- cellular components of Ca2+ signaling in activating endothelial secretion of vasoactive substances. | lld:pubmed |
| pubmed-article:7705461 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7705461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7705461 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7705461 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7705461 | pubmed:author | pubmed-author:SpatzMM | lld:pubmed |
| pubmed-article:7705461 | pubmed:author | pubmed-author:NikodijevicBB | lld:pubmed |
| pubmed-article:7705461 | pubmed:author | pubmed-author:McCarronR MRM | lld:pubmed |
| pubmed-article:7705461 | pubmed:author | pubmed-author:Nikodijevic-K... | lld:pubmed |
| pubmed-article:7705461 | pubmed:author | pubmed-author:StanimirovicD... | lld:pubmed |
| pubmed-article:7705461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7705461 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7705461 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:7705461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7705461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7705461 | pubmed:pagination | 1-8 | lld:pubmed |
| pubmed-article:7705461 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:7705461 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7705461 | pubmed:articleTitle | Signal transduction and Ca2+ uptake activated by endothelins in rat brain endothelial cells. | lld:pubmed |
| pubmed-article:7705461 | pubmed:affiliation | Stroke Branch, NINDS, NIH, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:7705461 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7705461 | lld:pubmed |
