| pubmed-article:7705224 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7705224 | lifeskim:mentions | umls-concept:C0600431 | lld:lifeskim |
| pubmed-article:7705224 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:7705224 | pubmed:dateCreated | 1995-5-5 | lld:pubmed |
| pubmed-article:7705224 | pubmed:abstractText | There is increasing evidence for bidirectional communication between glial cells and neurons. In this study, calcium signaling in primary glia/neuron cultures was investigated using video fluorescence imaging and fura-2. Glial cells in culture without neurons showed occasional spontaneous intracellular Ca2+ oscillations but not intercellular Ca2+ waves. By contrast, glial cells in culture with neurons showed frequent spontaneous Ca2+ oscillations as well as propagated intercellular Ca2+ waves. These spontaneous glial intercellular Ca2+ waves often emanated from sites of contact with neurons, but were only occasionally associated with increases in neuronal Ca2+. Mechanical stimulation of a single glial cell induced a glial intercellular Ca2+ wave which was similar in its temporal and spatial characteristics to spontaneous glial Ca2+ waves. Mechanically induced glial Ca2+ waves, but not spontaneous Ca2+ waves, evoked a transient increase in [Ca2+]i or a change in the pattern of spontaneous Ca2+ oscillations in a small percentage (< 10%) of neighboring neurons. Mechanical stimulation of a single neuron consistently evoked an intercellular Ca2+ wave in neighboring glial cells. These results suggest distinct mechanisms for direct glial-neuronal and neuronal-glial communication. These signaling pathways may play important roles in both function and pathology in the central nervous system. | lld:pubmed |
| pubmed-article:7705224 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7705224 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705224 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7705224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705224 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7705224 | pubmed:issn | 0378-5866 | lld:pubmed |
| pubmed-article:7705224 | pubmed:author | pubmed-author:CharlesA CAC | lld:pubmed |
| pubmed-article:7705224 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7705224 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:7705224 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7705224 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7705224 | pubmed:pagination | 196-206 | lld:pubmed |
| pubmed-article:7705224 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:meshHeading | pubmed-meshheading:7705224-... | lld:pubmed |
| pubmed-article:7705224 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7705224 | pubmed:articleTitle | Glia-neuron intercellular calcium signaling. | lld:pubmed |
| pubmed-article:7705224 | pubmed:affiliation | UCLA Department of Neurology 90024. | lld:pubmed |
| pubmed-article:7705224 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7705224 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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