| pubmed-article:7705024 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0079399 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0017785 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0063900 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:7705024 | lifeskim:mentions | umls-concept:C0080141 | lld:lifeskim |
| pubmed-article:7705024 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7705024 | pubmed:dateCreated | 1995-5-10 | lld:pubmed |
| pubmed-article:7705024 | pubmed:abstractText | The frequency of antibodies to glutamic acid decarboxylase (GAD) and insulin (IAA) in presymptomatic Type 1 diabetes mellitus with a positive test for antibodies to islet cell antigen (ICA) was examined. Thirty-two persons positive for ICA (> 10 JDF units) were tested 2 to 48 months before their ascertained onset of Type 1 diabetes. ICA was quantitated by immunofluorescence as JDF units, anti-GAD by radioimmunoprecipitation and anti-insulin by radioimmunoassay. There was a positive test for anti-GAD in 25 (78%), and for IAA in 23 (72%), of the 32 prediabetic ICA-positive subjects. Stratification according to age at the onset of diabetes showed differing frequencies of anti-GAD and IAA in the prediabetic stage. Thus the positivity rate for anti-GAD for 18 subjects older than 10 years at onset of diabetes was 83%, and for 14 aged 10 or younger at onset was 71%; conversely, the rate for IAA for 18 subjects older than 10 at onset was 56% and for 14 aged 10 or less at time of onset was 93% (p = 0.01). The frequency of anti-GAD was higher in females (88%) than males (71%) whereas the frequency of IAA was higher in males (82%) than in females (60%). Since autoantibodies to GAD and insulin occur in presymptomatic Type 1 diabetes with differences in frequencies by age and gender, the stimuli to autoimmunity may operate differently at different ages, and may also be gender-related. | lld:pubmed |
| pubmed-article:7705024 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7705024 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705024 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7705024 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705024 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705024 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7705024 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7705024 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7705024 | pubmed:issn | 0742-3071 | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:ElliottR BRB | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:MackayI RIR | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:RowleyM JMJ | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:KnowlesW JWJ | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:ZimmetP ZPZ | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:TuomiTT | lld:pubmed |
| pubmed-article:7705024 | pubmed:author | pubmed-author:PilcherC CCC | lld:pubmed |
| pubmed-article:7705024 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7705024 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:7705024 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7705024 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7705024 | pubmed:pagination | 866-71 | lld:pubmed |
| pubmed-article:7705024 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
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| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
| pubmed-article:7705024 | pubmed:meshHeading | pubmed-meshheading:7705024-... | lld:pubmed |
| pubmed-article:7705024 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7705024 | pubmed:articleTitle | Autoantibodies to glutamic acid decarboxylase and insulin in islet cell antibody positive presymptomatic type 1 diabetes mellitus: frequency and segregation by age and gender. | lld:pubmed |
| pubmed-article:7705024 | pubmed:affiliation | International Diabetes Institute, Caulfield General Medical Centre, Victoria, Australia. | lld:pubmed |
| pubmed-article:7705024 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7705024 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7705024 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7705024 | lld:pubmed |
