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pubmed-article:7696623pubmed:abstractTextKainic acid (KA)-induced seizures in adult rats have been reported to cause sprouting of mossy fibres in the inner molecular layer (IML) of the dentate gyrus. In the present study, using electron microscopic immunostaining for GAP-43 we found that 3 months after KA treatment, several GAP-43 positive terminals in the IML showed structural characteristics of mossy fibre boutons. No GAP-43-positive mossy fibre terminals were found in the normal projection areas of granule cells, thus indicating that newly synthesized GAP-43 is transported predominantly in the axonal branches actively undergoing remodelling. These results provide evidence of the involvement of GAP-43 in the structural remodelling of mossy fibres, and suggest a role of this protein in the functional activity of the sprouted mossy fibres as a consequence of KA-induced seizures.lld:pubmed
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pubmed-article:7696623pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7696623pubmed:articleTitleUltrastructural immunolocalization of GAP-43 in the sprouted mossy fibres of kainic acid lesioned rats.lld:pubmed
pubmed-article:7696623pubmed:affiliationIstituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.lld:pubmed
pubmed-article:7696623pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7696623pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed