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pubmed-article:7695045pubmed:abstractTextC57BL mice were depleted of macrophages by an intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (DCMDP), and control mice were uninjected or injected with empty liposomes. One day after injection, a proportion of the DCMDP-treated and control mice was continuously exposed to ethanol vapor for 4 days. Albumin fractions were separated from the sera of both ethanol-unexposed and ethanol-exposed animals and tested for cytotoxicity against a monolayer of A9 cells using two indicators of cytotoxicity: detachment of adherent cells and a decrease in the ability of cells to reduce tetrazolium. The results show that, in mice exposed to ethanol, macrophages are a major source of the acetaldehyde in circulating cytotoxic acetaldehyde-albumin complexes and presumably also of free acetaldehyde.lld:pubmed
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pubmed-article:7695045pubmed:articleTitleMacrophages are a major source of acetaldehyde in circulating acetaldehyde-albumin complexes formed after exposure of mice to ethanol.lld:pubmed
pubmed-article:7695045pubmed:affiliationDivision of Pathology Sciences, St. Mary's Hospital Medical School, Imperial College of Science, Technology, and Medicine, London, United Kingdom.lld:pubmed
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