| pubmed-article:7694370 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C1519726 | lld:lifeskim |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:7694370 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7694370 | pubmed:issue | 5137 | lld:pubmed |
| pubmed-article:7694370 | pubmed:dateCreated | 1993-12-21 | lld:pubmed |
| pubmed-article:7694370 | pubmed:abstractText | Interleukin-4 (IL-4) is an immunoregulatory cytokine produced by activated T lymphocytes to promote the growth and differentiation of cells that participate in immune defense. This study demonstrates the rapid activation of a specific DNA binding factor by IL-4. The IL-4 nuclear-activated factor (IL-4 NAF) appeared within minutes of IL-4 stimulation and recognized a specific DNA sequence found in the promoters of IL-4-responsive genes. Activation of this putative transcription factor required tyrosine phosphorylation, and antibodies specific for phosphotyrosine recognize the IL-4 NAF-DNA complex. Thus, IL-4 appears to transduce a signal to the nucleus through tyrosine phosphorylation of a latent DNA binding factor. | lld:pubmed |
| pubmed-article:7694370 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694370 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7694370 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7694370 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7694370 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7694370 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:7694370 | pubmed:author | pubmed-author:ReichN CNC | lld:pubmed |
| pubmed-article:7694370 | pubmed:author | pubmed-author:KotanidesHH | lld:pubmed |
| pubmed-article:7694370 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7694370 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:7694370 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:7694370 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7694370 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7694370 | pubmed:pagination | 1265-7 | lld:pubmed |
| pubmed-article:7694370 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7694370 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7694370 | pubmed:articleTitle | Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. | lld:pubmed |
| pubmed-article:7694370 | pubmed:affiliation | Graduate Program in Molecular and Cellular Biology, State University of New York at Stony Brook 11794. | lld:pubmed |
| pubmed-article:7694370 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7694370 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7694370 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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