| pubmed-article:7694190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7694190 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:7694190 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:7694190 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7694190 | lifeskim:mentions | umls-concept:C1514555 | lld:lifeskim |
| pubmed-article:7694190 | lifeskim:mentions | umls-concept:C0054535 | lld:lifeskim |
| pubmed-article:7694190 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7694190 | pubmed:dateCreated | 1993-12-13 | lld:pubmed |
| pubmed-article:7694190 | pubmed:abstractText | The effects of calphostin A on cytoplasmic calcium levels, receptor-mediated calcium release, and membrane input resistance were measured in neuroblastoma cells. Calphostin A is a lipophilic, light-sensitive perylenequinone that generates singlet oxygen when illuminated. It inhibits the activity of protein kinase C (IC50 = 250 nM), but only in the presence of light. Phorbol esters normally attenuate carbachol-evoked calcium release. This effect was blocked by simultaneous exposure to light and calphostin A (40 nM) for 30 min. At higher doses (0.5-1 microM) calphostin A also approximately doubled the resting calcium level and decreased cell input resistance by 51%. These toxic effects did not occur in the dark or after preincubation with the antioxidant alpha-tocopherol. These data support the hypothesis that the calphostins act by partitioning into the membrane and producing singlet oxygen and endoperoxides which then irreversibly modify protein kinase C and other membrane proteins and lipids. | lld:pubmed |
| pubmed-article:7694190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7694190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7694190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7694190 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7694190 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:7694190 | pubmed:author | pubmed-author:WangS SSS | lld:pubmed |
| pubmed-article:7694190 | pubmed:author | pubmed-author:ThompsonS HSH | lld:pubmed |
| pubmed-article:7694190 | pubmed:author | pubmed-author:MathewOO | lld:pubmed |
| pubmed-article:7694190 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7694190 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:7694190 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:7694190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7694190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7694190 | pubmed:pagination | 25-8 | lld:pubmed |
| pubmed-article:7694190 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7694190 | pubmed:meshHeading | pubmed-meshheading:7694190-... | lld:pubmed |
| pubmed-article:7694190 | pubmed:meshHeading | pubmed-meshheading:7694190-... | lld:pubmed |
| pubmed-article:7694190 | pubmed:meshHeading | pubmed-meshheading:7694190-... | lld:pubmed |
| pubmed-article:7694190 | pubmed:meshHeading | pubmed-meshheading:7694190-... | lld:pubmed |
| pubmed-article:7694190 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7694190 | pubmed:articleTitle | Membrane toxicity of the protein kinase C inhibitor calphostin A by a free-radical mechanism. | lld:pubmed |
| pubmed-article:7694190 | pubmed:affiliation | Department of Biological Sciences, Stanford University, Pacific Grove, CA 93950. | lld:pubmed |
| pubmed-article:7694190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7694190 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7694190 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7694190 | lld:pubmed |
