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pubmed-article:7693876pubmed:abstractTextMotor neurons in the spinal cord affected with bovine spinal muscular atrophy (SMA) were investigated immunohistochemically using antibodies against bovine ubiquitin. Anti-ubiquitin immunostained many chromatolytic and swollen degenerating motor neurons in the ventral horn of the SMA-affected spinal cord. The most severely swollen cells showed a lightly-stained center and a strongly-stained periphery after immunostaining. However, there were many dark, shrunken neurons in a more advanced stage that showed a completely negative reaction when immunostained. Motor neuron counts differed significantly between SMA-affected and normal animals at the lumbar intumescence and at the fourth lumbar neuromere, but not at the brachial intumescence or the second cervical level.lld:pubmed
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pubmed-article:7693876pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7693876pubmed:articleTitleReduced numbers and intense anti-ubiquitin immunostaining of bovine motor neurons affected with spinal muscular atrophy.lld:pubmed
pubmed-article:7693876pubmed:affiliationDepartment of Pathology, College of Veterinary Medicine, Kansas State University, Manhattan 66506.lld:pubmed
pubmed-article:7693876pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7693876pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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