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| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C1456669 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C0039371 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:7690819 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7690819 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7690819 | pubmed:dateCreated | 1993-10-21 | lld:pubmed |
| pubmed-article:7690819 | pubmed:abstractText | To understand the nature of the cytotoxic T cell response generated in human T lymphotropic virus type 1 (HTLV-1)-infected patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, we cloned CTL from the peripheral blood and cerebrospinal fluid from patients with neurologic diseases and demonstrated the presence of HLA-A2, A3, and B14 restricted responses to the HTLV-1 p40x (tax) protein. We identified the minimal amino acid residues within the epitopes required for binding and recognition by HLA-A2- and B14-restricted CTL, identified the critical residues within the peptide sequence defining the HLA-A2-restricted response, and demonstrated that CTL can lyse T cells infected with HTLV-1. This study shows that the CTL response to HTLV-1 tax in patients with neurologic diseases is heterogenous in nature and is not confined to patients of a single HLA haplotype or to a specific region of the tax protein. | lld:pubmed |
| pubmed-article:7690819 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7690819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690819 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7690819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7690819 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7690819 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:JonesG MGM | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:JacobsonSS | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:KoenigSS | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:RobinsonS MSM | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:BaselerM WMW | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:WoodsR MRM | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:NewellA JAJ | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:BooneEE | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:BrewahY AYA | lld:pubmed |
| pubmed-article:7690819 | pubmed:author | pubmed-author:AdelsbergerJ... | lld:pubmed |
| pubmed-article:7690819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7690819 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7690819 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:7690819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7690819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7690819 | pubmed:pagination | 3874-83 | lld:pubmed |
| pubmed-article:7690819 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7690819 | pubmed:meshHeading | pubmed-meshheading:7690819-... | lld:pubmed |
| pubmed-article:7690819 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7690819 | pubmed:articleTitle | Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease. | lld:pubmed |
| pubmed-article:7690819 | pubmed:affiliation | Department of Immunology, MedImmune, Inc., Gaithersburg, MD 20878. | lld:pubmed |
| pubmed-article:7690819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7690819 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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