| pubmed-article:7690249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C0023470 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C0010843 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C1414314 | lld:lifeskim |
| pubmed-article:7690249 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7690249 | pubmed:issue | 35 | lld:pubmed |
| pubmed-article:7690249 | pubmed:dateCreated | 1993-10-8 | lld:pubmed |
| pubmed-article:7690249 | pubmed:abstractText | The early growth response 1 (EGR-1) gene is induced by mitogens, differentiating stimuli, and certain genotoxic agents in diverse cell types. The present work has examined the effects of 1-(beta-D-arabinofuranosyl)cytosine (ara-C), an antileukemia agent that misincorporates into DNA, on EGR-1 expression. Treatment of HL-525 myeloid leukemia cells with ara-C was associated with transient increases in EGR-1 mRNA levels. Nuclear run-on assays showed that this effect is related at least in part to activation of EGR-1 gene transcription. Sequences responsive to ara-C-induced signals were determined by deletion analysis of the EGR-1 promoter. The results demonstrate that ara-C inducibility of the EGR-1 gene is conferred by a region containing six serum response or CC(A/T)6GG (CArG) motifs. Further analysis demonstrated that the first two distal or 5'-most CArG elements are functional in the ara-C response. An oligomer corresponding to the first CArG element also conferred ara-C inducibility of the minimal thymdine kinase gene promoter, while no inducibility was detectable using a similar oligomer containing a mutated CArG box. Other work has demonstrated that the nuclear serum response factor (SRF) interacts with the CArG box in the EGR-1 promoter and that the serine/threonine pp90rsk protein kinase phosphorylates SRF in vitro at sites phosphorylated in vivo. The present studies demonstrate that ara-C has little if any effect on cytosolic pp90rsk as determined by immunoblotting to assess electrophoretic mobility and by immune-complex kinase assays using S6 peptide as substrate.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7690249 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7690249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7690249 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7690249 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:7690249 | pubmed:author | pubmed-author:RubinEE | lld:pubmed |
| pubmed-article:7690249 | pubmed:author | pubmed-author:KufeDD | lld:pubmed |
| pubmed-article:7690249 | pubmed:author | pubmed-author:SaleemAA | lld:pubmed |
| pubmed-article:7690249 | pubmed:author | pubmed-author:BlenisJJ | lld:pubmed |
| pubmed-article:7690249 | pubmed:author | pubmed-author:SukhatmeVV | lld:pubmed |
| pubmed-article:7690249 | pubmed:author | pubmed-author:KharbandaSS | lld:pubmed |
| pubmed-article:7690249 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7690249 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:7690249 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:7690249 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7690249 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7690249 | pubmed:pagination | 9137-42 | lld:pubmed |
| pubmed-article:7690249 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7690249 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7690249 | pubmed:articleTitle | Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine. | lld:pubmed |
| pubmed-article:7690249 | pubmed:affiliation | Laboratory of Clinical Pharmacology, Dana-Farber Cancer Institute, Boston, Massachusetts. | lld:pubmed |
| pubmed-article:7690249 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7690249 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7690249 | lld:pubmed |
