| pubmed-article:7690155 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0080125 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0439605 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0947611 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C1509144 | lld:lifeskim |
| pubmed-article:7690155 | lifeskim:mentions | umls-concept:C0337051 | lld:lifeskim |
| pubmed-article:7690155 | pubmed:issue | 5127 | lld:pubmed |
| pubmed-article:7690155 | pubmed:dateCreated | 1993-10-4 | lld:pubmed |
| pubmed-article:7690155 | pubmed:abstractText | An iterative in vitro selection procedure was used to isolate a new class of catalytic RNAs (ribozymes) from a large pool of random-sequence RNA molecules. These ribozymes ligate two RNA molecules that are aligned on a template by catalyzing the attack of a 3'-hydroxyl on an adjacent 5'-triphosphate--a reaction similar to that employed by the familiar protein enzymes that synthesize RNA. The corresponding uncatalyzed reaction also yields a 3',5'-phosphodiester bond. In vitro evolution of the population of new ribozymes led to improvement of the average ligation activity and the emergence of ribozymes with reaction rates 7 million times faster than the uncatalyzed reaction rate. | lld:pubmed |
| pubmed-article:7690155 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7690155 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7690155 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7690155 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7690155 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7690155 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7690155 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:7690155 | pubmed:author | pubmed-author:SzostakJ WJW | lld:pubmed |
| pubmed-article:7690155 | pubmed:author | pubmed-author:BartelD PDP | lld:pubmed |
| pubmed-article:7690155 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7690155 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:7690155 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:7690155 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7690155 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7690155 | pubmed:pagination | 1411-8 | lld:pubmed |
| pubmed-article:7690155 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7690155 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7690155 | pubmed:articleTitle | Isolation of new ribozymes from a large pool of random sequences [see comment]. | lld:pubmed |
| pubmed-article:7690155 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:7690155 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7690155 | pubmed:publicationType | Comment | lld:pubmed |
| pubmed-article:7690155 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7690155 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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