| pubmed-article:7689776 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0019196 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0042749 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0005795 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C1710263 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0341439 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0750484 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0022885 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0392366 | lld:lifeskim |
| pubmed-article:7689776 | lifeskim:mentions | umls-concept:C0201773 | lld:lifeskim |
| pubmed-article:7689776 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7689776 | pubmed:dateCreated | 1993-9-30 | lld:pubmed |
| pubmed-article:7689776 | pubmed:abstractText | Seventy-three Swedish blood donors (52 men, 21 women; median age 36 years) repeatedly reactive for hepatitis C antibodies (anti-HCV C-100-3) were tested with a second-generation (2nd-gen) anti-HCV Elisa and a 4-band recombinant immunoblot assay (RIBA 2). These results were correlated to serum alanine aminotransferase (S-ALAT), liver morphology and viremia as detected by 'nested' polymerase chain reaction (PCR) based on primers from a 5'-noncoding sequence of the HCV genome. Thirty-five of 46 (76%) donors with positive 2nd-gen Elisa tests confirmed by RIBA 2 were PCR positive whereof 27 had histological findings compatible with chronic persistent hepatitis (CPH) and 7 had chronic active hepatitis (CAH). Ten of 56 (18%) 2nd-gen Elisa-positive donors were RIBA 2 negative (or indeterminate) and none of these had chronic hepatitis nor were PCR positive. Seventeen of 73 (23%) donors were 1st-gen Elisa positive but 2nd-gen Elisa negative. All of these were PCR negative and only 1 (6%) had chronic hepatitis (CPH). An elevated S-ALAT level (reference < 0.7 mu kat/l) was found in 26 2nd-gen Elisa and RIBA 2-positive donors of which 18 had CPH and 7 had CAH and all 25 were PCR positive. A normal S-ALAT level was found in 9 of 34 (26%) donors with chronic hepatitis (all had CPH) and positive PCR. We have found that blood donors with positive 2nd-gen anti-HCV Elisa tests confirmed by RIBA-2 and especially with a concomitant elevated S-ALAT are highly likely to be viremic as demonstrated by PCR and to have chronic hepatitis. | lld:pubmed |
| pubmed-article:7689776 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7689776 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689776 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7689776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7689776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689776 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7689776 | pubmed:issn | 0042-9007 | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:LindholmAA | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:HermodssonSS | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:von SydowMM | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:LindhGG | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:WeilandOO | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:FrydenAA | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:WidellAA | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:FobergUU | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:MånssonA SAS | lld:pubmed |
| pubmed-article:7689776 | pubmed:author | pubmed-author:SherWW | lld:pubmed |
| pubmed-article:7689776 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7689776 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:7689776 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7689776 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7689776 | pubmed:pagination | 32-7 | lld:pubmed |
| pubmed-article:7689776 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7689776 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7689776 | pubmed:articleTitle | Second-generation hepatitis C Elisa antibody tests confirmed by the four-antigen recombinant immunoblot assay correlate well with hepatitis C viremia and chronic liver disease in Swedish blood donors. | lld:pubmed |
| pubmed-article:7689776 | pubmed:affiliation | Department of Infectious Diseases, Ostra Hospital, Göteborg, Sweden. | lld:pubmed |
| pubmed-article:7689776 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7689776 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7689776 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7689776 | lld:pubmed |
