| pubmed-article:7689526 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7689526 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:7689526 | lifeskim:mentions | umls-concept:C0019163 | lld:lifeskim |
| pubmed-article:7689526 | lifeskim:mentions | umls-concept:C0369335 | lld:lifeskim |
| pubmed-article:7689526 | lifeskim:mentions | umls-concept:C0860069 | lld:lifeskim |
| pubmed-article:7689526 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:7689526 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7689526 | pubmed:dateCreated | 1993-9-27 | lld:pubmed |
| pubmed-article:7689526 | pubmed:abstractText | Approximately 90% of subjects with chronic hepatitis resulting from hepatitis C virus infection have hepatitis C virus RNA in serum. However, the prevalence of hepatitis C virus RNA in serum from subjects with hepatitis C virus antibody associated with persistent normal liver biochemical values is unclear. Do these subjects have resolved or continuing infection with hepatitis C virus? The aim of this study was to examine whether subjects with hepatitis C virus antibody but normal ALT levels had evidence of ongoing infection. Our study population was divided into four groups. Groups 1, 2 and 3 comprised hepatitis C virus antibody-positive volunteer blood donors. Group 1 was made up of subjects found to be hepatitis C virus antibody-positive on enzyme-linked immunosorbent assay with persistent abnormal ALT levels (59 donors: 53 positive on recombinant immunoblot assay and 6 indeterminate). Group 2 members were hepatitis C virus antibody positive, with persistent normal ALT levels (50 donors: 39 positive on recombinant immunoblot assay and 11 indeterminate). Group 3 members were hepatitis C virus seropositive but negative on second-generation recombinant immunoblot assay (n = 48). Twenty patients (not blood donors) with chronic liver disease who were anti-hepatitis C virus seronegative were used as controls (group 4). Serum samples from all four groups were assayed for hepatitis C virus RNA on reverse transcription and a 40-cycle polymerase chain reaction with a combination of primers from the highly conserved 5'-noncoding and less-conserved third and fourth nonstructural regions. All assays were confirmed on hybridization with an internal probe.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7689526 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7689526 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689526 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7689526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689526 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689526 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7689526 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7689526 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:7689526 | pubmed:author | pubmed-author:ParsonsCC | lld:pubmed |
| pubmed-article:7689526 | pubmed:author | pubmed-author:BishopG AGA | lld:pubmed |
| pubmed-article:7689526 | pubmed:author | pubmed-author:McCaughanG... | lld:pubmed |
| pubmed-article:7689526 | pubmed:author | pubmed-author:WilesDD | lld:pubmed |
| pubmed-article:7689526 | pubmed:author | pubmed-author:McGuinnessP... | lld:pubmed |
| pubmed-article:7689526 | pubmed:author | pubmed-author:LiemBB | lld:pubmed |
| pubmed-article:7689526 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7689526 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:7689526 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7689526 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7689526 | pubmed:pagination | 485-90 | lld:pubmed |
| pubmed-article:7689526 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
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| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
| pubmed-article:7689526 | pubmed:meshHeading | pubmed-meshheading:7689526-... | lld:pubmed |
| pubmed-article:7689526 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7689526 | pubmed:articleTitle | Detection of serum hepatitis C virus RNA in HCV antibody-seropositive volunteer blood donors. | lld:pubmed |
| pubmed-article:7689526 | pubmed:affiliation | A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown NSW, Australia. | lld:pubmed |
| pubmed-article:7689526 | pubmed:publicationType | Journal Article | lld:pubmed |
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