| pubmed-article:7687318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7687318 | lifeskim:mentions | umls-concept:C0153381 | lld:lifeskim |
| pubmed-article:7687318 | lifeskim:mentions | umls-concept:C0031740 | lld:lifeskim |
| pubmed-article:7687318 | lifeskim:mentions | umls-concept:C0002563 | lld:lifeskim |
| pubmed-article:7687318 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:7687318 | pubmed:issue | 8864 | lld:pubmed |
| pubmed-article:7687318 | pubmed:dateCreated | 1993-8-17 | lld:pubmed |
| pubmed-article:7687318 | pubmed:abstractText | Photodynamic therapy with intravenous photosensitising drugs has been shown to be effective in the ablation of superficial cancers, but long-lasting photosensitivity is a serious disadvantage. Similar photosensitivity is a feature of certain types of porphyria. We present the first report of tumour necrosis brought about by photodynamic activation of a temporary endogenous porphyrin accumulation, after an oral dose of the haem precursor, 5-aminolaevulinic acid. In 4 patients, quantitative fluorescence microscopy showed that accumulation of the photoactive intermediate protoporphyrin IX peaked after 4-6 h in 4 oral cavity squamous cell carcinomas, returning to background in 24 h. Irradiation with non-thermal red laser light caused tumour necrosis in 3 patients. | lld:pubmed |
| pubmed-article:7687318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7687318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7687318 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7687318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7687318 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7687318 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:7687318 | pubmed:author | pubmed-author:BownS GSG | lld:pubmed |
| pubmed-article:7687318 | pubmed:author | pubmed-author:MacRobertA... | lld:pubmed |
| pubmed-article:7687318 | pubmed:author | pubmed-author:SpeightP MPM | lld:pubmed |
| pubmed-article:7687318 | pubmed:author | pubmed-author:GrantW EWE | lld:pubmed |
| pubmed-article:7687318 | pubmed:author | pubmed-author:HopperCC | lld:pubmed |
| pubmed-article:7687318 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7687318 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:7687318 | pubmed:volume | 342 | lld:pubmed |
| pubmed-article:7687318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7687318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7687318 | pubmed:pagination | 147-8 | lld:pubmed |
| pubmed-article:7687318 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7687318 | pubmed:meshHeading | pubmed-meshheading:7687318-... | lld:pubmed |
| pubmed-article:7687318 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7687318 | pubmed:articleTitle | Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid. | lld:pubmed |
| pubmed-article:7687318 | pubmed:affiliation | National Medical Laser Centre, University College London Medical School, UK. | lld:pubmed |
| pubmed-article:7687318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7687318 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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