| pubmed-article:7686307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7686307 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:7686307 | lifeskim:mentions | umls-concept:C1519877 | lld:lifeskim |
| pubmed-article:7686307 | lifeskim:mentions | umls-concept:C0524891 | lld:lifeskim |
| pubmed-article:7686307 | lifeskim:mentions | umls-concept:C0178555 | lld:lifeskim |
| pubmed-article:7686307 | pubmed:issue | 5117 | lld:pubmed |
| pubmed-article:7686307 | pubmed:dateCreated | 1993-7-27 | lld:pubmed |
| pubmed-article:7686307 | pubmed:abstractText | The diversity of the T cell receptor repertoire is generated by rearrangement of gene elements in immature thymocytes. To identify a thymic signal that induces this rearrangement, a variety of agents were tested for their ability to induce rearrangement of the T cell receptor beta gene in suspensions of thymocytes from mouse embryos at day 14 of gestation. Of 16 agents tested, only interleukin-7 (IL-7) induced V(D)J gene rearrangement and sustained expression of the RAG-1 and RAG-2 genes, which are known to control rearrangement. These data implicate IL-7, a cytokine that is abundantly expressed in embryonic thymus, in driving gene rearrangement during early T cell development. | lld:pubmed |
| pubmed-article:7686307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7686307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7686307 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7686307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7686307 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7686307 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:7686307 | pubmed:author | pubmed-author:DurumS KSK | lld:pubmed |
| pubmed-article:7686307 | pubmed:author | pubmed-author:MueggeKK | lld:pubmed |
| pubmed-article:7686307 | pubmed:author | pubmed-author:VilaM PMP | lld:pubmed |
| pubmed-article:7686307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7686307 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:7686307 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:7686307 | pubmed:geneSymbol | RAG-1 | lld:pubmed |
| pubmed-article:7686307 | pubmed:geneSymbol | RAG-2 | lld:pubmed |
| pubmed-article:7686307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7686307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7686307 | pubmed:pagination | 93-5 | lld:pubmed |
| pubmed-article:7686307 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:7686307 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7686307 | pubmed:articleTitle | Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. | lld:pubmed |
| pubmed-article:7686307 | pubmed:affiliation | Biological Carcinogenesis and Development Program, Program Resources Inc./Dyncorp, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702. | lld:pubmed |
| pubmed-article:7686307 | pubmed:publicationType | Journal Article | lld:pubmed |
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