| pubmed-article:7686212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C1367475 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7686212 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:7686212 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7686212 | pubmed:dateCreated | 1993-7-23 | lld:pubmed |
| pubmed-article:7686212 | pubmed:abstractText | Accessory cell surface molecules, such as T cell antigen CD2 and its ligand lymphocyte function-associated antigen 3 (LFA-3; CD58), are critical costimulatory pathways for optimal T cell activation in response to antigens. Interaction of CD2 with cell surface LFA-3 not only increases T cell/accessory cell adhesion, but also induces signal transduction events involved in the regulation of T cell responses. In this report, we show that specific interactions of LFA-3 with CD2 can result in T cell unresponsiveness to antigenic or mitogenic stimuli in vitro. By deletion of certain regions of the extracellular domain of LFA-3, we localized the CD2 binding site to the first domain of LFA-3. We then demonstrated that a soluble, purified first domain-LFA-3/IgG1 fusion protein (LFA3TIP) interacts with CD2 and binds to the same CD2 epitope as purified multimeric or cell surface-expressed LFA-3. LFA3TIP inhibits tetanus toxoid, hepatitis B surface antigen, anti-CD3 mAb, Con A, and phytohemagglutinin P-induced T cell proliferation, as well as xenogeneic and allogeneic mixed lymphocyte reactions (MLR). Unlike anti-LFA-3 or anti-CD2 monoclonal antibodies (mAbs) which inhibit T cell responses by blocking LFA-3/CD2 binding, LFA3TIP is capable of rendering T cells unresponsive to antigenic stimuli in situations where T cell activation is independent of CD2/LFA-3 interactions. Furthermore, LFA3TIP, but not blocking anti-CD2 mAbs, is capable of inducing T cell unresponsiveness to secondary stimulation in allogeneic MLR. This inhibition of T cell responses by LFA3TIP occurs through a different mechanism from that of mAbs to LFA-3 or CD2. | lld:pubmed |
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| pubmed-article:7686212 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7686212 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7686212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7686212 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7686212 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:MeierWW | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:RosaM DMD | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:HochmanP SPS | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:TizardRR | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:MillerG TGT | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:WallnerB PBP | lld:pubmed |
| pubmed-article:7686212 | pubmed:author | pubmed-author:BixlerS ASA | lld:pubmed |
| pubmed-article:7686212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7686212 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7686212 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:7686212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7686212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7686212 | pubmed:pagination | 211-22 | lld:pubmed |
| pubmed-article:7686212 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7686212 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7686212 | pubmed:articleTitle | Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses. | lld:pubmed |
| pubmed-article:7686212 | pubmed:affiliation | Biogen, Inc, Cambridge, Massachusetts 02142. | lld:pubmed |
| pubmed-article:7686212 | pubmed:publicationType | Journal Article | lld:pubmed |
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