| pubmed-article:7685159 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7685159 | lifeskim:mentions | umls-concept:C0227578 | lld:lifeskim |
| pubmed-article:7685159 | lifeskim:mentions | umls-concept:C0021549 | lld:lifeskim |
| pubmed-article:7685159 | lifeskim:mentions | umls-concept:C1419206 | lld:lifeskim |
| pubmed-article:7685159 | lifeskim:mentions | umls-concept:C0682970 | lld:lifeskim |
| pubmed-article:7685159 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:7685159 | lifeskim:mentions | umls-concept:C0597551 | lld:lifeskim |
| pubmed-article:7685159 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7685159 | pubmed:dateCreated | 1993-7-2 | lld:pubmed |
| pubmed-article:7685159 | pubmed:abstractText | In this study we report that a synthetic peptide of the effector domain of rab3A (rab3AL(33-48)) stimulates both amylase secretion and inositol 1,4,5-trisphosphate (IP3)-accumulation in digitonin-permeabilized pancreatic acini in an analogous way to cholecystokinin-octapeptide (CCK8). Maximum CCK8-induced IP3-accumulation was observed at five seconds after addition of CCK8 to the acini. Maximum rab3AL(33-48)-induced IP3-production occurred 15 to 30 seconds after addition of rab3AL(33-48); then the acinar IP3 content declined towards the basal level. Heparin, an inhibitor of IP3 binding to its receptor, inhibited both rab3AL(33-48)- and CCK8-stimulated amylase secretion without affecting the response to vasoactive intestinal polypeptide. rab3AL(33-48) had no effect in intact acini, indicating that the site of action of rab3AL(33-48) is intracellular. We conclude that rab-like small molecular weight GTP-binding proteins regulate phospholipase C activity and thereby amylase secretion from inside of the cell. | lld:pubmed |
| pubmed-article:7685159 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7685159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7685159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7685159 | pubmed:month | May | lld:pubmed |
| pubmed-article:7685159 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7685159 | pubmed:author | pubmed-author:CasparyW FWF | lld:pubmed |
| pubmed-article:7685159 | pubmed:author | pubmed-author:SteinJJ | lld:pubmed |
| pubmed-article:7685159 | pubmed:author | pubmed-author:ZeuzemSS | lld:pubmed |
| pubmed-article:7685159 | pubmed:author | pubmed-author:PiiperAA | lld:pubmed |
| pubmed-article:7685159 | pubmed:author | pubmed-author:Stryjek-Kamin... | lld:pubmed |
| pubmed-article:7685159 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7685159 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:7685159 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:7685159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7685159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7685159 | pubmed:pagination | 1030-6 | lld:pubmed |
| pubmed-article:7685159 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7685159 | pubmed:meshHeading | pubmed-meshheading:7685159-... | lld:pubmed |
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| pubmed-article:7685159 | pubmed:meshHeading | pubmed-meshheading:7685159-... | lld:pubmed |
| pubmed-article:7685159 | pubmed:meshHeading | pubmed-meshheading:7685159-... | lld:pubmed |
| pubmed-article:7685159 | pubmed:meshHeading | pubmed-meshheading:7685159-... | lld:pubmed |
| pubmed-article:7685159 | pubmed:meshHeading | pubmed-meshheading:7685159-... | lld:pubmed |
| pubmed-article:7685159 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7685159 | pubmed:articleTitle | A synthetic peptide of the effector domain of rab3A stimulates inositol 1,4,5-trisphosphate production in digitonin-permeabilized pancreatic acini. | lld:pubmed |
| pubmed-article:7685159 | pubmed:affiliation | Department of Internal Medicine, University of Frankfurt/Main, Germany. | lld:pubmed |
| pubmed-article:7685159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7685159 | pubmed:publicationType | In Vitro | lld:pubmed |
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