| pubmed-article:7684681 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7684681 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:7684681 | lifeskim:mentions | umls-concept:C0019733 | lld:lifeskim |
| pubmed-article:7684681 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:7684681 | lifeskim:mentions | umls-concept:C0920679 | lld:lifeskim |
| pubmed-article:7684681 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:7684681 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7684681 | pubmed:dateCreated | 1993-7-1 | lld:pubmed |
| pubmed-article:7684681 | pubmed:abstractText | We used the human processing defective cell line 174CEM.T2 (T2) to identify potential cytotoxic T lymphocyte (CTL) epitopes of human proteins. Exogenously added peptides can increase the number of properly folded HLA-A2.1 molecules on the cell surface of T2 cells, as shown by immunofluorescence measurements using the mouse monoclonal antibody BB7.2 (anti-HLA-A2.1) and fluorescein isothiocyanate-labeled goat anti-mouse F(ab')2 antibody. The peptides were selected on the basis of a computer score derived from the recently described HLA-A2.1 specific motif. Analysis of the influenza matrix protein showed that 15 out of 35 high-scoring peptides up-regulate the expression of HLA-A2.1 molecules on the T2 cell surface. The combination of the computer scoring program and an immunofluorescence-based peptide binding assay allows rapid detection of potential CTL target peptides. | lld:pubmed |
| pubmed-article:7684681 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7684681 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684681 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7684681 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7684681 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7684681 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:MeliefC JCJ | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:D'AmaroJJ | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:KenemansPP | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:KastW MWM | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:DrijfhoutJ... | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:NijmanH WHW | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:HoubiersJ GJG | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:VierboomM PMP | lld:pubmed |
| pubmed-article:7684681 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:7684681 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7684681 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:7684681 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7684681 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7684681 | pubmed:pagination | 1215-9 | lld:pubmed |
| pubmed-article:7684681 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7684681 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7684681 | pubmed:articleTitle | Identification of peptide sequences that potentially trigger HLA-A2.1-restricted cytotoxic T lymphocytes. | lld:pubmed |
| pubmed-article:7684681 | pubmed:affiliation | Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:7684681 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7684681 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7684681 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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