| pubmed-article:7683660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0069139 | lld:lifeskim |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7683660 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7683660 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:7683660 | pubmed:dateCreated | 1993-6-4 | lld:pubmed |
| pubmed-article:7683660 | pubmed:abstractText | Insulin induces the serine phosphorylation of the nucleolar protein nucleolin at subnanomolar concentrations in differentiated 3T3-442A cells. The stimulation is biphasic with phosphorylation reaching a maximum at 10 pM insulin and then declining to only 40% of basal levels at insulin concentrations of 1 microM. These changes are rapid, reaching half-maximal after 4 min and maximal after 15 min of incubation. The cell-permeable casein kinase II inhibitor 5,6-dichlorobenzimidazole-riboside prevents the insulin-stimulated phosphorylation of nucleolin suggesting that casein kinase II may mediate this effect of the hormone. Insulin-like growth factor 1 mimics the action of insulin on dephosphorylation of nucleolin at nanomolar concentrations suggesting that the latter effect may be mediated by insulin-like growth factor 1 receptors. Insulin treatment of 3T3-442A cells also results in a stimulation of RNA efflux from isolated, intact cell nuclei. The dose dependence of insulin-induced nucleolin phosphorylation and insulin-stimulated RNA efflux from intact cell nuclei are almost identical. Insulin induces an increase in the RNA efflux at subnanomolar concentrations in 3T3-442A adipocytes, while high (micromolar) concentrations of insulin inhibited the efflux of RNA. These data indicate that insulin regulates the phosphorylation/dephosphorylation of nucleolin, possibly via stimulation of casein kinase II, and this may play a role in regulation of the RNA efflux from nuclei. | lld:pubmed |
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| pubmed-article:7683660 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7683660 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7683660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7683660 | pubmed:month | May | lld:pubmed |
| pubmed-article:7683660 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7683660 | pubmed:author | pubmed-author:KahnC RCR | lld:pubmed |
| pubmed-article:7683660 | pubmed:author | pubmed-author:OlsonM OMO | lld:pubmed |
| pubmed-article:7683660 | pubmed:author | pubmed-author:CheathamBB | lld:pubmed |
| pubmed-article:7683660 | pubmed:author | pubmed-author:CsermelyPP | lld:pubmed |
| pubmed-article:7683660 | pubmed:author | pubmed-author:SchnaiderTT | lld:pubmed |
| pubmed-article:7683660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7683660 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:7683660 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:7683660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7683660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7683660 | pubmed:pagination | 9747-52 | lld:pubmed |
| pubmed-article:7683660 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7683660 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7683660 | pubmed:articleTitle | Insulin induces the phosphorylation of nucleolin. A possible mechanism of insulin-induced RNA efflux from nuclei. | lld:pubmed |
| pubmed-article:7683660 | pubmed:affiliation | Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215. | lld:pubmed |
| pubmed-article:7683660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7683660 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7683660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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