| pubmed-article:7683413 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7683413 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:7683413 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:7683413 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:7683413 | lifeskim:mentions | umls-concept:C0872184 | lld:lifeskim |
| pubmed-article:7683413 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7683413 | pubmed:dateCreated | 1993-6-1 | lld:pubmed |
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| pubmed-article:7683413 | pubmed:abstractText | Hepatocyte nuclear factor (HNF)-3 alpha, -3 beta, and -3 gamma are liver transcription factors that mediate the coordinate expression of a number of hepatocyte-specific genes. The HNF-3 proteins share DNA-binding-domain homology among themselves and with the Drosophila homeotic protein forkhead (fkh). The HNF-3/fkh DNA-binding domain constitutes an uncharacterized protein motif that recognizes its cognate DNA binding site as a monomer. Additional HNF-3/fkh-related proteins are known to be required for determination events during embryogenesis in Drosophila and Xenopus. In this report, we describe the isolation of nine additional HNF-3/fkh homologue (HFH) clones from rodent tissue cDNAs by using both low-stringency hybridization and a polymerase chain reaction protocol. Many of the HFH genes exhibit a tissue-restricted expression pattern and are transcribed in tissues other than liver, including brain, kidney, lung, and intestine. The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development. | lld:pubmed |
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| pubmed-article:7683413 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7683413 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7683413 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7683413 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7683413 | pubmed:month | May | lld:pubmed |
| pubmed-article:7683413 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:TanTT | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:LalFF | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:KüngJJ | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:QianXX | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:CostaR HRH | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:OverdierD GDG | lld:pubmed |
| pubmed-article:7683413 | pubmed:author | pubmed-author:ClevidenceD... | lld:pubmed |
| pubmed-article:7683413 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7683413 | pubmed:day | 1 | lld:pubmed |
