| pubmed-article:7682405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0314589 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0237753 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:7682405 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:7682405 | pubmed:issue | 1-4 | lld:pubmed |
| pubmed-article:7682405 | pubmed:dateCreated | 1993-5-7 | lld:pubmed |
| pubmed-article:7682405 | pubmed:abstractText | In this paper we investigated the role played by human immunodeficiency virus type 1 (HIV-1) in the pathogenesis of peripheral blood (PB) cytopenias of AIDS patients. The in vitro growth of PB granulocyte/macrophage progenitors (CFU-GM) was investigated in 45 HIV-1 seropositive (+) individuals at different stages of the disease. The number of circulating CFU-GM was significantly (p < 0.01) lower in AIDS patients (stages WR V-VI) than in HIV-1(+) asymptomatic individuals (stages WR I-II). Moreover, the presence of gag p 24 in the plasma and/or viral isolation from PB mononuclear cells of HIV-1(+) individuals was inversely correlated (p < 0.01) with the number of circulating CFU-GM, irrespectively with the stage of the disease. Viral isolates obtained from one asymptomatic and four symptomatic HIV-1(+) individuals were tested on the in vitro growth of normal hematopoietic progenitor (CD34+) cells, purified from PB of healthy donors. All the different viral isolates showed a dose-dependent inhibition of CD34+ cells, in the absence of either productive or latent infection. This suppressive effect was completely reversed by preincubating the different viral isolates with a polyclonal anti-gp 120 antibody before adding to normal CD34+ cells. These findings suggest a direct involvement of active viral replication products in the progressive impairment of hematopoiesis, characteristic of HIV-1(+) individuals in spite of the lack of a productive or latent infection of CD34+ hematopoietic progenitors. | lld:pubmed |
| pubmed-article:7682405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7682405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7682405 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7682405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7682405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7682405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7682405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7682405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7682405 | pubmed:issn | 0304-8608 | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:La PlacaMM | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:ReM CMC | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:RanieriSS | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:MonariPP | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:FurliniGG | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:ZauliGG | lld:pubmed |
| pubmed-article:7682405 | pubmed:author | pubmed-author:RamazzottiEE | lld:pubmed |
| pubmed-article:7682405 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7682405 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:7682405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7682405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7682405 | pubmed:pagination | 53-64 | lld:pubmed |
| pubmed-article:7682405 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
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| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:meshHeading | pubmed-meshheading:7682405-... | lld:pubmed |
| pubmed-article:7682405 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7682405 | pubmed:articleTitle | The impaired number of circulating granulocyte/macrophage progenitors (CFU-GM) in human immunodeficiency virus-type 1 infected subjects correlates with an active HIV-1 replication. | lld:pubmed |
| pubmed-article:7682405 | pubmed:affiliation | Institute of Microbiology, University of Bologna, Italy. | lld:pubmed |
| pubmed-article:7682405 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7682405 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7682405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7682405 | lld:pubmed |
