| pubmed-article:7681470 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7681470 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:7681470 | lifeskim:mentions | umls-concept:C1955926 | lld:lifeskim |
| pubmed-article:7681470 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7681470 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7681470 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:7681470 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7681470 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7681470 | pubmed:dateCreated | 1993-4-28 | lld:pubmed |
| pubmed-article:7681470 | pubmed:abstractText | Long-term bone marrow cultures have been useful in determining gene expression patterns in pre-B cells and in the identification of cytokines such as interleukin 7 (IL-7). We have developed a culture system to selectively grow populations of B lineage restricted progenitors (pro-B cells) from murine bone marrow. Pro-B cells do not grow in response to IL-7, Steel locus factor (SLF), or a combination of the two. c-kit, the SLF receptor, and the IL-7 receptor are both expressed by pro-B cells, indicating that the lack of response is not simply due to the absence of receptors. Furthermore, SLF is not necessary for the growth of pro-B cells since they could be expanded on a stromal line derived from Steel mice that produces no SLF. IL-7 responsiveness in pre-B cells is associated with an increase in n-myc expression and is correlated with immunoglobulin (Ig) gene rearrangements. Although members of the ets family of transcription factors and the Pim-1 kinase are expressed by pro-B cells, n-myc is not expressed. Pro-B cells maintain Ig genes in the germline configuration, which is correlated with a low level of recombination activating genes 1 and 2 (Rag-1 and 2) mRNA expression, but high expression of sterile mu and terminal deoxynucleotidyl transferase. Pro-B cells are unable to grow separated from the stromal layer by a porous membrane, indicating that stromal contact is required for growth. These results suggest that pro-B cells are dependent on alternative growth signals derived from bone marrow stroma and can be distinguished from pre-B cells by specific patterns of gene expression. | lld:pubmed |
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| pubmed-article:7681470 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7681470 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7681470 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7681470 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7681470 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:7681470 | pubmed:author | pubmed-author:WitteO NON | lld:pubmed |
| pubmed-article:7681470 | pubmed:author | pubmed-author:WilliamsD ADA | lld:pubmed |
| pubmed-article:7681470 | pubmed:author | pubmed-author:FaustE AEA | lld:pubmed |
| pubmed-article:7681470 | pubmed:author | pubmed-author:ToksozDD | lld:pubmed |
| pubmed-article:7681470 | pubmed:author | pubmed-author:SaffranD CDC | lld:pubmed |
| pubmed-article:7681470 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7681470 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7681470 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:7681470 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7681470 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7681470 | pubmed:pagination | 915-23 | lld:pubmed |
| pubmed-article:7681470 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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