| pubmed-article:7681349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7681349 | lifeskim:mentions | umls-concept:C0005768 | lld:lifeskim |
| pubmed-article:7681349 | lifeskim:mentions | umls-concept:C0175505 | lld:lifeskim |
| pubmed-article:7681349 | lifeskim:mentions | umls-concept:C0005823 | lld:lifeskim |
| pubmed-article:7681349 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:7681349 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7681349 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:7681349 | pubmed:dateCreated | 1993-4-26 | lld:pubmed |
| pubmed-article:7681349 | pubmed:abstractText | We sought to determine whether arginine vasopressin (AVP) modulates arterial pressure (AP) by a receptor-mediated action in the nucleus reticularis rostroventrolateralis (nRVL). Immunocytochemical labeling with an antiserum against a synthetic AVP conjugate revealed a discrete although modest presumptive neuropeptidergic innervation of the nRVL. Electron microscopic analysis of vasopressinergic processes in the nRVL revealed that AVP-like immunoreactivity (AVP-LI) was primarily in axons and axon terminals. Immunoreactive terminals contained numerous small clear vesicles and large dense core vesicles and formed synapses with unlabeled dendrites. In the nRVL, retrograde transport-immunofluorescence data demonstrated close appositions between vasopressinergic beaded processes and a compact subambigual column of reticulospinal neurons labeled by deposits of cholera toxin beta-subunit into the thoracic spinal cord. Similar methods were used to define the origins of the AVP-afferent projection to nRVL. These retrograde transport-immunofluorescence studies demonstrated numerous retrogradely labeled neurons in the hypothalamus, including the paraventricular nucleus (PVN), after injections of a retrograde tracer, Fluoro-Gold into the ventrolateral medulla. However, double-labeled neurons were rare and confirmed a diffuse AVP afferent innervation of the sympathoexcitatory area. Microinjection of AVP into the nRVL in anesthetized rats produced a large dose-related increase in AP different from control at a dose of 1 pmol or higher. AVP injected intravenously elevated AP only at significantly higher doses. Microinjections of AVP into the nucleus tractus solitarii (NTS) had a smaller effect whereas into the caudal ventrolateral medulla exerted no effect on AP. Bilateral microinjections of an AVP antagonist, d(CH2)5[Tyr(Me)2]AVP into the nRVL produced no change in AP but blocked the increase produced by subsequent injections of AVP. An acute hemorrhage produced by withdrawal of 2 ml of blood from the femoral vein did not alter AP. However, bilateral microinjections of the AVP antagonist into the nRVL 5 min after hemorrhage decreased AP. In contrast, the AVP-antagonist injected intravenously after hemorrhage had no effect on AP. Our data suggest that under conditions demanding increased sympathetic drive to maintain AP, such as hemorrhage, a functional AVP receptor mechanism via terminals in the nRVL may be activated to restore normal levels of AP. | lld:pubmed |
| pubmed-article:7681349 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7681349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7681349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7681349 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7681349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7681349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7681349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7681349 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7681349 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:7681349 | pubmed:author | pubmed-author:MillerR ERE | lld:pubmed |
| pubmed-article:7681349 | pubmed:author | pubmed-author:ReisD JDJ | lld:pubmed |
| pubmed-article:7681349 | pubmed:author | pubmed-author:AnwarMM | lld:pubmed |
| pubmed-article:7681349 | pubmed:author | pubmed-author:CannataM AMA | lld:pubmed |
| pubmed-article:7681349 | pubmed:author | pubmed-author:RuggieroD ADA | lld:pubmed |
| pubmed-article:7681349 | pubmed:author | pubmed-author:GómezR ERE | lld:pubmed |
| pubmed-article:7681349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7681349 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:7681349 | pubmed:volume | 604 | lld:pubmed |
| pubmed-article:7681349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7681349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7681349 | pubmed:pagination | 90-105 | lld:pubmed |
| pubmed-article:7681349 | pubmed:dateRevised | 2008-8-16 | lld:pubmed |
| pubmed-article:7681349 | pubmed:meshHeading | pubmed-meshheading:7681349-... | lld:pubmed |
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| pubmed-article:7681349 | pubmed:meshHeading | pubmed-meshheading:7681349-... | lld:pubmed |
| pubmed-article:7681349 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7681349 | pubmed:articleTitle | Vasopressinergic mechanisms in the nucleus reticularis lateralis in blood pressure control. | lld:pubmed |
| pubmed-article:7681349 | pubmed:affiliation | Instituto de Investigaciones Cardiológicas, Buenos Aires, Argentina. | lld:pubmed |
| pubmed-article:7681349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7681349 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7681349 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7681349 | lld:pubmed |
