| pubmed-article:7680664 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0051300 | lld:lifeskim |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0002198 | lld:lifeskim |
| pubmed-article:7680664 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7680664 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7680664 | pubmed:dateCreated | 1993-4-13 | lld:pubmed |
| pubmed-article:7680664 | pubmed:abstractText | alpha 2-Macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2M-R/LRP) is a broad specificity receptor that may function in lipoprotein metabolism, proteinase regulation, and growth factor regulation. In this study, we demonstrated that alpha 2M-R/LRP expression in macrophages can be markedly decreased by LPS and by IFN-gamma. Regulation of alpha 2M-R/LRP in RAW 264.7 cells was demonstrated at the mRNA, antigen, and receptor-function levels. In receptor-function studies, the decrease in alpha 2M-R/LRP expression was detected as a 90% decrease in the Bmax or maximum receptor binding capacity for activated alpha 2M after treatment with LPS or IFN-gamma. Western blot analysis of whole cell lysates demonstrated significant loss of alpha 2M-R/LRP heavy-chain. Northern blot analysis of poly(A)+ RNA revealed a marked decrease in alpha 2M-R/LRP mRNA after treatment with LPS (79% decrease) or IFN-gamma (70% decrease). Other cytokines, including tumor necrosis factor-alpha, transforming growth factor-beta-1, and interleukin-6 did not regulate alpha 2M-R/LRP. The ability of LPS and IFN-gamma to regulate alpha 2M-R/LRP was confirmed in experiments with primary cultures of murine bone marrow macrophages. These studies demonstrate that macrophage alpha 2M-R/LRP is subject to significant downregulation by physiologically significant cytokines and signaling macromolecules. | lld:pubmed |
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| pubmed-article:7680664 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7680664 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7680664 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7680664 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7680664 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7680664 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:7680664 | pubmed:author | pubmed-author:QuesenberryP... | lld:pubmed |
| pubmed-article:7680664 | pubmed:author | pubmed-author:GoniasS LSL | lld:pubmed |
| pubmed-article:7680664 | pubmed:author | pubmed-author:LaMarreJJ | lld:pubmed |
| pubmed-article:7680664 | pubmed:author | pubmed-author:KittlerE LEL | lld:pubmed |
| pubmed-article:7680664 | pubmed:author | pubmed-author:WolfB BBB | lld:pubmed |
| pubmed-article:7680664 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7680664 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7680664 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7680664 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7680664 | pubmed:pagination | 1219-24 | lld:pubmed |
| pubmed-article:7680664 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7680664 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7680664 | pubmed:articleTitle | Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma. | lld:pubmed |
| pubmed-article:7680664 | pubmed:affiliation | Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908. | lld:pubmed |
