| pubmed-article:7679106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7679106 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:7679106 | lifeskim:mentions | umls-concept:C0073337 | lld:lifeskim |
| pubmed-article:7679106 | lifeskim:mentions | umls-concept:C0086168 | lld:lifeskim |
| pubmed-article:7679106 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:7679106 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7679106 | pubmed:dateCreated | 1993-3-8 | lld:pubmed |
| pubmed-article:7679106 | pubmed:abstractText | The metabolic and mitogenic actions of insulin have been proposed to be mediated by cellular serine/threonine kinases such as the ribosomal protein S6 kinases pp70-S6 (pp70-S6 kinase) and pp90rsk and the erk-encoded mitogen-activated protein kinases (pp42mapk and pp44mapk). Rapamycin completely blocked activation of pp70-S6 kinase by insulin in 3T3-L1 adipocytes, but did not inhibit insulin-stimulated glucose transport, translocation of GLUT4 to the cell surface, or activation of pp90rsk or pp44mapk by insulin. Concordant with the inhibition of kinase activity, rapamycin prevented the insulin-induced decrease in mobility of pp70-S6 kinase visualized by SDS-polyacrylamide gel electrophoresis, reflecting a reduction in the hormone-stimulated phosphorylation of the enzyme. The structurally related macrolide, FK506, had no effect on pp70-S6 kinase or hexose uptake. These data demonstrate that rapamycin blocks insulin activation of pp70-S6 kinase in 3T3-L1 adipocytes and that pp70-S6 kinase is not required in the signaling pathway leading to insulin-stimulated glucose transport. | lld:pubmed |
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| pubmed-article:7679106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7679106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7679106 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7679106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7679106 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7679106 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7679106 | pubmed:author | pubmed-author:BirnbaumM JMJ | lld:pubmed |
| pubmed-article:7679106 | pubmed:author | pubmed-author:BlenisJJ | lld:pubmed |
| pubmed-article:7679106 | pubmed:author | pubmed-author:HausdorffS... | lld:pubmed |
| pubmed-article:7679106 | pubmed:author | pubmed-author:FingarD CDC | lld:pubmed |
| pubmed-article:7679106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7679106 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:7679106 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:7679106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7679106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7679106 | pubmed:pagination | 3005-8 | lld:pubmed |
| pubmed-article:7679106 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7679106 | pubmed:meshHeading | pubmed-meshheading:7679106-... | lld:pubmed |
| pubmed-article:7679106 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7679106 | pubmed:articleTitle | Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. | lld:pubmed |
| pubmed-article:7679106 | pubmed:affiliation | Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:7679106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7679106 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7679106 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7679106 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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