| pubmed-article:7678654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0282519 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0046242 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0121925 | lld:lifeskim |
| pubmed-article:7678654 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:7678654 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7678654 | pubmed:dateCreated | 1993-2-19 | lld:pubmed |
| pubmed-article:7678654 | pubmed:abstractText | In an ongoing effort to develop novel nonnucleoside, specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitors, a series of 3-[(pyridylmethyl)amino]- and 3-[(phenylmethyl)amino]-2-pyridinone derivatives was synthesized and tested for HIV-1 RT inhibitory activity. The more potent compounds have a 2'-methoxy group and 4'- and/or 5'-aliphatic substituents on the pyridyl and phenyl rings. Several of the more potent compounds were also evaluated for antiviral activity in MT-4 cell culture. From this series of compounds, 3-[N-[(5-ethyl-2-methoxy-6-methyl-3-pyridyl)methyl]amino]-5-ethyl-6- methylpyridin-2(1H)-one (6) was selected for clinical evaluation. | lld:pubmed |
| pubmed-article:7678654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7678654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7678654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7678654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7678654 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7678654 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:SaariW SWS | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:ThomasC MCM | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:HoffmanJ MJM | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:RooneyC SCS | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:WilliamsT MTM | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:WaiJ SJS | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:FisherT ETE | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:BambergerD... | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:HudcoskyR JRJ | lld:pubmed |
| pubmed-article:7678654 | pubmed:author | pubmed-author:MacToughS CSC | lld:pubmed |
| pubmed-article:7678654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7678654 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:7678654 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:7678654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7678654 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7678654 | pubmed:pagination | 249-55 | lld:pubmed |
| pubmed-article:7678654 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:meshHeading | pubmed-meshheading:7678654-... | lld:pubmed |
| pubmed-article:7678654 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7678654 | pubmed:articleTitle | Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one. | lld:pubmed |
| pubmed-article:7678654 | pubmed:affiliation | Merck Research Laboratories, West Point, Pennsylvania 19486. | lld:pubmed |
| pubmed-article:7678654 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:7678654 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7678654 | lld:pubmed |
