| pubmed-article:7677228 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7677228 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7677228 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7677228 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:7677228 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:7677228 | lifeskim:mentions | umls-concept:C1325847 | lld:lifeskim |
| pubmed-article:7677228 | pubmed:issue | 25 Suppl | lld:pubmed |
| pubmed-article:7677228 | pubmed:dateCreated | 1995-10-19 | lld:pubmed |
| pubmed-article:7677228 | pubmed:abstractText | An animal model system was developed to study the mechanisms resulting in allergic sensitization. Local allergen exposure via the airways and the lung stimulated an allergen-specific immunoglobulin E (IgE) response that was paralleled by the development of increased airway responsiveness (AR). It was found that CD4+ T cells of local draining lymph nodes played an important role in the regulation of these events. Stimulation of allergen-specific T cells requires interaction between major histocompatibility complex (MHC) class II molecules (expressed on antigen-presenting cells), peptide (presented on MHC) and the T cell receptor. Allergen sensitization stimulated T cells that expressed a restricted T cell receptor V beta (TCR-V beta) elements. Each allergen stimulated different V beta elements, and sensitization to the same allergen resulted in a different pattern of TCR-V beta stimulation in different lymphoid tissues. Some of these T cells had pro-allergenic effects, whereas others were able to inhibit the development of the allergic response, including the development of increased AR. These data indicate that the local T cell response regulates the type of immune response that evolves following local allergen sensitization. | lld:pubmed |
| pubmed-article:7677228 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7677228 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7677228 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7677228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7677228 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7677228 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7677228 | pubmed:issn | 0105-4538 | lld:pubmed |
| pubmed-article:7677228 | pubmed:author | pubmed-author:RenzHH | lld:pubmed |
| pubmed-article:7677228 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7677228 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:7677228 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7677228 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7677228 | pubmed:pagination | 15-9 | lld:pubmed |
| pubmed-article:7677228 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:meshHeading | pubmed-meshheading:7677228-... | lld:pubmed |
| pubmed-article:7677228 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7677228 | pubmed:articleTitle | T cell receptor-V beta repertoire in allergen-specific sensitization and increased airway responsiveness. | lld:pubmed |
| pubmed-article:7677228 | pubmed:affiliation | Institut für Klinische Chemie und Biochemie, Freie Universität Berlin, Germany. | lld:pubmed |
| pubmed-article:7677228 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7677228 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:7677228 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
